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Titolo:
QUANTITATIVE CHANGES IN RAT RENIN SECRETORY GRANULES AFTER ACUTE AND CHRONIC STIMULATION OF THE RENIN SYSTEM
Autore:
RASCH R; JENSEN BL; NYENGAARD JR; SKOTT O;
Indirizzi:
ODENSE UNIV,DEPT PHYSIOL,WINSLOWPARKEN 19 DK-5000 ODENSE C DENMARK ODENSE UNIV,DEPT PHYSIOL DK-5000 ODENSE C DENMARK AARHUS UNIV,DEPT CELL BIOL DK-8000 AARHUS DENMARK AARHUS UNIV,STEREOL RES LAB DK-8000 AARHUS DENMARK
Titolo Testata:
Cell and tissue research
fascicolo: 3, volume: 292, anno: 1998,
pagine: 563 - 571
SICI:
0302-766X(1998)292:3<563:QCIRRS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENALAPRIL; RELEASE; CELLS; MICE;
Keywords:
JUXTAGLOMERULAR CELLS; STEREOLOGY; DISECTOR; SALT DIETS; ENALAPRIL; RENAL PERFUSION PRESSURE; RAT (WISTAR);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R. Rasch et al., "QUANTITATIVE CHANGES IN RAT RENIN SECRETORY GRANULES AFTER ACUTE AND CHRONIC STIMULATION OF THE RENIN SYSTEM", Cell and tissue research, 292(3), 1998, pp. 563-571

Abstract

In order to study the cellular mode of renin secretion, stereologicalmethods were used to estimate number and volume of rat renin secretory granules during stimulation of the renin system. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min increased plasma reninconcentration (PRC) twofold, but did not significantly change the number of renin granules per arteriole or the renin-containing volume of the arteriole. Chronic stimulation was achieved by a combination of low-salt diet and inhibition of angiotensin-converting enzyme (ACE) for 14 days, and resulted in a 36-fold increase in PRC, a 20-fold increasein the number of granules per arteriole, and a 17-fold increase in the arteriolar volume that contained renin. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min in the chronically stimulated rats increased PRC further (1.6-fold), and significantly reduced the number of granules per arteriole by 4000 (45% reduction), but did not change the renin-containing arteriolar volume significantly. The averagerenin granule size was 0.35 mu m(3) with no significant differences among the groups. We conclude that recruited granular cells contribute significantly to renin release, and that all granular cells along the arteriole participate in secretory responses. The reduced number of renin granules after acute stimulation is compatible with exocytosis as the dominating mechanism of renin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:07:35