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Titolo:
SUPPRESSION OF INDUCIBLE VENTRICULAR-TACHYCARDIA BY IBUTILIDE IN PATIENTS WITH CORONARY-ARTERY DISEASE
Autore:
WOOD MA; STAMBLER BS; ELLENBOGEN KA; GILLIGAN DM; PERRY KT; WAKEFIELD LK; VANDERLUGT JT;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT MED CARDIOL,BOX 980053 RICHMOND VA 23298 HUNTER HOLMES MCGUIRE VET ADM MED CTR RICHMOND VA 00000
Titolo Testata:
The American heart journal
fascicolo: 6, volume: 135, anno: 1998,
parte:, 1
pagine: 1048 - 1054
SICI:
0002-8703(1998)135:6<1048:SOIVBI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED ELECTRICAL-STIMULATION; ANTIARRHYTHMIC AGENTS; ATRIAL-FLUTTER; I-KR; FIBRILLATION; SOTALOL; TACHYARRHYTHMIAS; ARRHYTHMIAS; TERMINATION; AMIODARONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Wood et al., "SUPPRESSION OF INDUCIBLE VENTRICULAR-TACHYCARDIA BY IBUTILIDE IN PATIENTS WITH CORONARY-ARTERY DISEASE", The American heart journal, 135(6), 1998, pp. 1048-1054

Abstract

Background Recent studies suggest that class III antiarrhythmic agents may have enhanced efficacy in the treatment of ventricular tachycardia. This study describes the first clinical assessment of the new class III agent ibutilide to suppress inducible monomorphic ventricular tachycardia (VT) in human beings. Methods and Results Fifty-five patients with coronary artery disease and inducible sustained monomorphic VT at baseline received either low (0.005 mg/kg + 0.001 mg/kg, load and maintenance infusion, respectively), middle (0.01 mg/kg + 0.002 mg/kg),or high dose (0.02 mg/kg + 0.004 mg/kg) infusions of ibutilide followed by repeat programmed ventricular stimulation. The mean age of the study group was 65.5 +/- 9.5 years and mean left ventricular ejection fraction was 36% +/- 11%. Of 48 evaluable patients, 21 (44%) were rendered noninducible after ibutilide, with no difference in efficacy amongthe three dosing groups (p = 0.83). Ventricular effective refractory periods, QTc interval, and ventricular monophasic action potential duration were prolonged over baseline at all tested cycle lengths. The QTc and action potential prolongation were dose related. Serious drug-related adverse reactions included sustained polymorphic VT in two patients (3.6%), spontaneous monomorphic VT in one patient (1.8%), heart block in one patient (1.8%), and hypotension in one patient (1.8%). Conclusions Ibutilide prolongs ventricular repolarization in human beings and demonstrates efficacy in suppressing inducible monomorphic VT. Significant cardiovascular side effects occurred in 12.7% of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:14:20