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Titolo:
PERSISTENCE OF THE BIPHASIC VENTILATORY RESPONSE TO HYPOXIA IN PRETERM INFANTS
Autore:
MARTIN RJ; DIFIORE JM; JANA L; DAVIS RL; MILLER MJ; COLES SK; DICK TE;
Indirizzi:
RAINBOW BABIES & CHILDRENS HOSP,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PEDIAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED CLEVELAND OH 44106
Titolo Testata:
The Journal of pediatrics
fascicolo: 6, volume: 132, anno: 1998,
pagine: 960 - 964
SICI:
0022-3476(1998)132:6<960:POTBVR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN KITTENS; CENTRAL ORIGIN; OXYGEN; APNEA; SLEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Martin et al., "PERSISTENCE OF THE BIPHASIC VENTILATORY RESPONSE TO HYPOXIA IN PRETERM INFANTS", The Journal of pediatrics, 132(6), 1998, pp. 960-964

Abstract

Objective: To characterize postnatal maturation of the biphasic ventilatory response to hypoxia in order to determine whether it persists beyond the first weeks of life in preterm infants, and the contributions of respiratory frequency and tidal volume to this response. Methods:Stable preterm infants were studied at two postnatal ages, 2 to 3 weeks (n = 12) and 4 to 8 weeks (n = 12), before hospital discharge at 35weeks (range, 33 to 38 weeks) of postconceptional age. Infants were exposed to 5 minutes of 15% (or 13%) inspired oxygen; ventilation, oxygen saturation, end-tidal partial pressure of carbon dioxide, and heartrate were simultaneously recorded. Results: Minute ventilation exhibited a characteristic biphasic response to hypoxia at both postnatal ages, regardless of the development of periodic breathing. At both ages there was a transient increase in tidal volume, which peaked at 1 minute, accompanied by a sustained decrease in respiratory frequency as a result of significant prolongation of expiratory time. Conclusion: Thecharacteristic biphasic ventilatory response to hypoxia persists intothe second month of postnatal life in preterm infants. We speculate that this finding is consistent with the prolonged vulnerability of such infants to neonatal apnea.

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Documento generato il 30/11/20 alle ore 09:52:15