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Titolo:
INVESTIGATIONS TO LOW-DOSE LOCO-REGIONAL THROMBOLYSIS OF ISOLATED THROMBOSES OF THE LEG WITH ACTILYSE(R) (RT-PA) - PART I - THE EFFECTIVITYOF THE THROMBOLYSIS
Autore:
GROHMANN G; KAUFMANN U; LINDLOH C; POHLMANN G; EIDNER G; BRANDSTADT A; MULLER S;
Indirizzi:
FRIEDRICH SCHILLER UNIV,INNERE MED KLIN 3 D-07740 JENA GERMANY
Titolo Testata:
Perfusion
fascicolo: 5, volume: 11, anno: 1998,
pagine: 220 -
SICI:
0935-0020(1998)11:5<220:ITLLTO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
GER
Keywords:
VENOUS LEG THROMBOSIS; LOCO-REGIONAL THROMBOLYSIS; RT-PA; CUMULATED TOTAL DOSE; ARNESEN-SCORE; APPLICATION TIME; SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G. Grohmann et al., "INVESTIGATIONS TO LOW-DOSE LOCO-REGIONAL THROMBOLYSIS OF ISOLATED THROMBOSES OF THE LEG WITH ACTILYSE(R) (RT-PA) - PART I - THE EFFECTIVITYOF THE THROMBOLYSIS", Perfusion, 11(5), 1998, pp. 220

Abstract

We investigated the effect of different dosages of Actilyse(R) (rt-PA), different infusion volume and different time of application during loco-regional thrombolysis in the isolated venous thrombosis of the leg. In 45 patients rt-PA was applicated in a dosage of 2.5 mg/h via a vein of the sicking foot. The volume of infusion varied between 12.5 ml/h and 125 ml/h, the infusion time was 2, 4 and 2 x 4 h, respectively,per day: group A - 5 mg/50 ml/2 h, group B - 10 mg/100 ml/4 h, group C - 10 mg/500 ml/4 h, group D - 10 mg/250 ml/4 h, group E - 10 mg/50 ml/4 h, The number of patients in each group was between 6 and 10, Heparin was applicated simultaneously and continuously in a dose effectingthe PTT. A control group obtained heparin only in an equal dose. A phlebography took place before and after 4 to 5 cycles of lysis, The evaluation was carried out by means of the scores from Arnesen and Marder, respectively, The two scores showed a good correlation, In the following evaluation the results of lysis were divided into 4 groups: 1., substantial lysis: improvement >50%, 2, moderate lysis: improvement between 10 and 50%, 3., no lysis: improvement between ii and 10%, 4, deterioration: increase of score. All groups given rt-PA showed a better result than those given heparin only, The dose-groups D and E showed significant better results than group A-C, while group E with 60% substantial lysis was better than group D, but not significantly different. There were only differences in trend in the groups D and E without statistical significance between the result in the crural, popliteal and femoral region. The time of anamnesis, number of lysis-cycles, rt-PA-dose related to body mass and sex had now statistical influence to the effect of lysis. The cumulated general dose was the highest in the dose groups D and E, It was differently between all groups, In one case (= 2.2%) the lysis was interrupted because of an anaphylactic reaction. There were 2 major bleedings (= 4.4%) and minor bleddings in three cases (= 6.6%), The loco-regional lysis of isolated venous thromboses ofthe legs should be carried out with at least 20 mg rt-PA at day over a minimum application time of 8 h, The infusion volume had no significant influence to our results, More investigations are necessary.

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Documento generato il 25/11/20 alle ore 08:59:44