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Titolo:
EFFECTS OF A STANDARDIZED MISTLETOE PREPARATION ON METASTATIC B16 MELANOMA COLONIZATION IN MARINE LUNGS
Autore:
WEBER K; MENGS U; SCHWARZ T; HAJTO T; HOSTANSKA K; ALLEN TR; WEYHENMEYER R; LENTZEN H;
Indirizzi:
MADAUS AG,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY MADAUS AG D-51109 COLOGNE GERMANY RRC RES & CONSULTING CO LTD ITINGEN SWITZERLAND UNIV ZURICH HOSP,DEPT INTERNAL MED ZURICH SWITZERLAND
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 5, volume: 48, anno: 1998,
pagine: 497 - 502
SICI:
0004-4172(1998)48:5<497:EOASMP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-SPECIFIC LECTIN; EXTRACT; CELLS; THERAPY; MICE; INTERLEUKIN-6; INHIBITION; EXPRESSION; CYTOKINE; INVIVO;
Keywords:
B16 MELANOMA, METASTASIS, MOUSE; CANCER IMMUNOTHERAPY; LEKTINOL(R); MISTLETOE EXTRACT; PHYTOTHERAPY; VISCUM ALBUM AGGLUTININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Weber et al., "EFFECTS OF A STANDARDIZED MISTLETOE PREPARATION ON METASTATIC B16 MELANOMA COLONIZATION IN MARINE LUNGS", Arzneimittel-Forschung, 48(5), 1998, pp. 497-502

Abstract

The immune response-modifying drug Lektinol(R) is a mistletoe preparation which is standardized with respect to bioactive viscum album agglutinin, the most active component of mistletoe. The present study was designed to evaluate the antimetastatic effects of this preparation following intravenous injection of B16 melanoma cells into mice. The standardized mistletoe extract was administered intravenously in doses of100, 1000 or 5000 mu l/kg (equivalent to 3, 30 or 150 ng/kg of viscumalbum agglutinin) once daily for three weeks. An inhibition of mean pulmonary metastatic colonization of 58 to 95%, as measured by the number of melanoma cells on lung tissue slides, and a significant decreaseof percentage of bronchoalveolar lavage pigmented cells were observed. In addition, a correlation of this antimetastatic activity with cellular immune parameters was investigated. In lavage fluids from the tumor-bearing mice, there was a 5 to 6-fold significant increase in the percentage of MAC-1(+) (CD11b/CD18) immunocompetent macrophages in comparison with cells from vehicle-treated animals. The percentages of double-positive immature CD4(+)8(+) thymocytes were significantly increased in animals treated with the standardized mistletoe extract. There were no signs of treatment-related toxicity. The results of this study indicate that the standardized mistletoe extract shows antimetastatic activity against B16 melanoma lung colonization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:03:36