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Titolo:
MUCINOUS CYSTADENOCARCINOMA OF THE BREAST
Autore:
KOENIG C; TAVASSOLI FA;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT GYNECOL & BREAST PATHOL,ALASKA AVE & 14TH ST WASHINGTON DC 20306
Titolo Testata:
The American journal of surgical pathology
fascicolo: 6, volume: 22, anno: 1998,
pagine: 698 - 703
SICI:
0147-5185(1998)22:6<698:MCOTB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLOID CARCINOMA;
Keywords:
MUCINOUS CYSTADENOCARCINOMA; BREAST; ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; MIB-1; CYTOKERATIN 7; CYTOKERATIN 20;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
C. Koenig e F.A. Tavassoli, "MUCINOUS CYSTADENOCARCINOMA OF THE BREAST", The American journal of surgical pathology, 22(6), 1998, pp. 698-703

Abstract

Four unusual cases of primary mammary mucinous cystadenocarcinoma composed predominantly of tall columnar cells with abundant intracytoplasmic mucin are reported, they were multicystic and appeared virtually identical to mucinous cystadenocarcinomas of the ovary and pancreas. Three of the women were white and one was black, they ranged in age from49 to 67 years (average 58), and they had tumors that ranged from 0.8to 19 cm in diameter. Microscopically, the tumors were characterized by cystic spaces lined by predominantly bland-appearing columnar mucinous cells with stratification, tufting, and papillary formations. Varying degrees of cytologic atypia were focally evident, with gradual loss of the intracytoplasmic mucin and transformation to an eosinophilic squamoid cell population. Multifocal invasion generally emanated from these eosinophilic. squamoid areas in all cases. All four tumors displayed immunoreactivity for MIB-1 (Ki-67) in a relatively high percentage of cells and failed to show immunoreactivity for estrogen receptors and progesterone receptors. All four stained positively with cytokeratin 7 (CK7) but were negative with cytokeratin 20 (CK20). Mastectomy and axillary lymph node dissection were performed in three cases and lumpectomy with lymph node dissection in the remaining case. Lymph node metastases, identified in only one patient, retained the distinctive morphology. Three of the patients are alive without evidence of disease 11, 22, and 23 months after the diagnosis; the fourth is a recent case. These tumors are a ran, clinicopathologically distinct type of primary breast carcinoma that should be distinguished from typical mucinous(colloid) carcinomas of the boast and, more importantly, metastases from other sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:04:16