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Titolo:
ANGIOIMMUNOBLASTIC LYMPHOMA (AILD-TYPE T-CELL LYMPHOMA) WITH HYPERPLASTIC GERMINAL-CENTERS
Autore:
REE HJ; KADIN ME; KIKUCHI M; KO YH; GO JH; SUZUMIYA J; KIM DS;
Indirizzi:
SAMSUNG MED CTR,DEPT DIAGNOST PATHOL,KANGNAM GU,50 ILWON DONG SEOUL 135710 SOUTH KOREA HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR BOSTON MA 00000 FUKUOKA UNIV,SCH MED FUKUOKA 81401 JAPAN
Titolo Testata:
The American journal of surgical pathology
fascicolo: 6, volume: 22, anno: 1998,
pagine: 643 - 655
SICI:
0147-5185(1998)22:6<643:AL(TLW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTER B-CELLS; ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; BCL-6 PROTEIN; DISEASE; NODES;
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSGAMMAGLOBULINEMIA; ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA; GERMINAL CENTER; INTRAFOLLICULAR T CELLS; BCL-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Ree et al., "ANGIOIMMUNOBLASTIC LYMPHOMA (AILD-TYPE T-CELL LYMPHOMA) WITH HYPERPLASTIC GERMINAL-CENTERS", The American journal of surgical pathology, 22(6), 1998, pp. 643-655

Abstract

Angioimmunoblastic T-cell lymphoma (or angioimmunoblastic lymphadenopathy with dysgammaglobulinemia [AILD]) was originally considered to bean abnormal immune reaction in which reactive follicles with germinalcenters (GCs) an usually absent. When hyperplastic GCs are present along with an angioimmunoblastic reaction, the lesion has been interpreted as a benign hyperimmune reaction. We report seven patients with angioimmunoblastic T-cell lymphoma (AITL) who initially had hyperplastic GCs, shown to be malignant lymphoma by further studies and clinical follow-up. Clonal T-cell populations were observed in all specimens evaluated, and sequential biopsies showed histologic progression to typical AITL in two patients. Clinical presentation was characterized by generalized lymphadenopathy of acute onset, constitutional symptoms, hepatosplenomegaly, skin rash, and polyclonal hypergammaglobulinemia in five patients; regional adenopathy preceded generalized adenopathy in two patients. Five patients had rapid progression of disease, and three patients whose treatment was delayed due to inadequate evidence to diagnose lymphoma died of infection. The initial biopsy findings of each patient were similar and showed angioimmunoblastic proliferation, hyperplastic GCs with ill-defined borders, and interfollicular tingible-body macrophages. These GCs differed from occasional residual follicles of typical AITL in that the GCs were enlarged and hyperplasia of follicular dendritic cells was not seen. Diagnostic clear cells were not observed. Apoptotic bodies were markedly increased and bcl-2(+) lymphocytes were sparse compared with typical AITL. Results of in situ hybridization for Epstein-Barr virus were positive in each case. We conclude that hyperplastic germinal centers with ill-defined borders and frequent interfollicular tingible-body macrophages occur in a histologic variant of AITL that is necessary to recognize for early diagnosis and treatment.

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Documento generato il 19/09/20 alle ore 09:23:54