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Titolo:
LPL PROMOTER -93T G TRANSITION INFLUENCES FASTING AND POSTPRANDIAL PLASMA TRIGLYCERIDES RESPONSE IN AFRICAN-AMERICANS AND HISPANICS/
Autore:
TALMUD PJ; HALL S; HOLLERAN S; RAMAKRISHNAN R; GINSBERG HN; HUMPHRIES SE;
Indirizzi:
UNIV LONDON UNIV COLL,SCH MED,CTR GENET CARDIOVASC DISORDERS,TORRINGTON PL LONDON WC1E 6JJ ENGLAND COLUMBIA PRESBYTERIAN MED CTR,DEPT MED NEW YORK NY 10032
Titolo Testata:
Journal of lipid research
fascicolo: 6, volume: 39, anno: 1998,
pagine: 1189 - 1196
SICI:
0022-2275(1998)39:6<1189:LP-GTI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE GENE; FAMILIAL COMBINED HYPERLIPIDEMIA; MYOCARDIAL-INFARCTION SURVIVORS; MISSENSE MUTATION; DEFICIENCY; EXPRESSION; ATHEROSCLEROSIS; ASSOCIATIONS; ASN291SER; VARIANTS;
Keywords:
LPL PROMOTER VARIANT; POSTPRANDIAL RESPONSE; PLASMA TG LEVELS; AFRICAN-AMERICANS; HISPANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Talmud et al., "LPL PROMOTER -93T G TRANSITION INFLUENCES FASTING AND POSTPRANDIAL PLASMA TRIGLYCERIDES RESPONSE IN AFRICAN-AMERICANS AND HISPANICS/", Journal of lipid research, 39(6), 1998, pp. 1189-1196

Abstract

The lipoprotein lipase (LPL) promoter -93T/G transition has previously been reported as having a triglyceride (Tg)-lowering effect, whereasthe D9N variant has been shown to have a Tg-raising effect. These twovariants were studied in 66 healthy subjects of Hispanic and 42 subjects of African-American origin, who had participated in a study of postprandial lipemia. While the allele frequency of the -93G was significantly different in the Hispanics and African Americans (0.09: 95% CI 0.04-0.13 and 0.28: 95% CI 0.19-0.38; P = 0.0001, respectively), the N9allele frequency was not different (0.06: 95% CI 0.02-0.1 and 0.05: 95% CI 0.002-0.093, respectively). Linkage disequilibrium between the -93T/G and D9N was highly significant in Hispanics (Delta = 0.67. P = 0.0001), compared to Delta = 0.09 (NS) in African-Americans. In the combined group, compared to individuals with the common genotype (TT/DD; n = 71) with fasting plasma Tg of 1.34 (+/-4.5% SEM) mmol/l, carriers of the G/D haplotype (TG/DD + GG/DD; n = 25) had significantly lower plasma Tg levels of 1.08 (+/-10% SEM) mmol/l (P < 0.02). After the fat meal, compared to individuals with neither mutation, TT/DD, the effectof the G/D haplotype was to reduce significantly postprandial Tg (P <0.036), Retinyl palmitate concentration at 5 hrs was significantly lower in G/D carriers than TT/DD individuals (P < 0.05), The lipid-raising effect of the N9 allele in carriers of the -93G (TG/DN + GG/DN) andeffect on postprandial Tg clearance was not significant in this group, Thus carriers of the G/D haplotype have lower fasting plasma Tg and reduced alimentary lipemia. This allele may be associated with reducedrisk of coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:43:35