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Titolo:
FACTORS RELATED TO THE PRESENCE OF IGA CLASS ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN ULCERATIVE-COLITIS
Autore:
ESTEVE M; MALLOLAS J; KLAASSEN J; ABADLACRUZ A; GONZALEZHUIX F; CABRE E; FERNANDEZBANARES F; MENACHO M; CONDOM E; MARTIRAGUE J; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA DEL CANYET S-N BADALONA 08916 SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL BADALONA 08916 SPAIN HOSP JOSEP TRUETA,DEPT GASTROENTEROL GIRONA SPAIN HOSP ST LLORENC,DEPT GASTROENTEROL VILADECANS SPAIN CIUTAT SANITARIA UNIV BELLVITGE,DEPT PATHOL LHOSPITALET LLOBR CATALONIA SPAIN CIUTAT SANITARIA UNIV BELLVITGE,DEPT SURG LHOSPITALET LLOBR CATALONIASPAIN
Titolo Testata:
The American journal of gastroenterology
fascicolo: 4, volume: 93, anno: 1998,
pagine: 615 - 618
SICI:
0002-9270(1998)93:4<615:FRTTPO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; POUCH-ANAL ANASTOMOSIS; PRIMARY SCLEROSING CHOLANGITIS; AUTOANTIBODIES; PROCTOCOLECTOMY; MARKER; SERA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Esteve et al., "FACTORS RELATED TO THE PRESENCE OF IGA CLASS ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN ULCERATIVE-COLITIS", The American journal of gastroenterology, 93(4), 1998, pp. 615-618

Abstract

Objectives: Few studies have assessed the IgA antineutrophil cytoplasmic antibody (ANCA) positivity in ulcerative colitis patients and there is no information about factors related to its synthesis and its status after colectomy. The aims of the study were to assess the serum IgA ANCA prevalence in ulcerative colitis patients, both nonoperated andoperated, and to determine the clinical factors related to this positivity. Methods: Fifty-four ulcerative colitis patients, 63 ulcerative colitis colectomized patients (32 with Brooke's ileostomy and 31 with deal pouch anal anastomosis), and 24 controls were studied. Antineutrophil cytoplasmic antibodies were detected by specific indirect immunofluorescent assays. Results: The percentage of IgA ANCA was significantly higher in patients with heal pouch anal anastomosis (45%) than in patients with Brooke's ileostomy (22%). There were no differences related to the presence of pouchitis in ileal pouch anal anastomosis patients. Patients with nonoperated extensive colitis (47%) had a significantly higher percentage of IgA ANCA than patients with proctitis (19%). Total percentage of ANCA (IgA and/or IgG) tended to be higher in ulcerative colitis and in patients with ileal pouch anal anastomosis than in patients with Brooke's ileostomy. However, in ileal pouch anal anastomosis patients, ANCA positivity was mainly due to exclusive IgA production Conclusions: A substantial percentage of ulcerative colitis patients, and especially colectomized patients with heal pouch anal anastomosis, had IgA ANCA, suggesting that ANCA production in ulcerative colitis might be stimulated by an immune reaction in the intestinal mucosa. (C) 1998 by Am. Cell. of Gastroenterology.

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Documento generato il 29/11/20 alle ore 09:44:26