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Titolo:
MATCHED UNRELATED HUMAN UMBILICAL-CORD BLOOD TRANSPLANTATION FOR X-LINKED ADRENOLEUKODYSTROPHY
Autore:
KAPELUSHNIK J; VARADI G; NAGLER A;
Indirizzi:
HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANT IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT BONE MARROW TRANSPLANT IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,ISRAEL UNRELATED CORD BLOOD BANK IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 3, volume: 20, anno: 1998,
pagine: 257 - 259
SICI:
1077-4114(1998)20:3<257:MUHUBT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; BRAIN MR OBSERVATIONS; PLACENTAL-BLOOD; DISEASE; CELLS;
Keywords:
ADRENOLEUKODYSTROPHY; VERY-LONG-CHAIN FATTY ACIDS; HUMAN UMBILICAL CORD BLOOD; MATCHED UNRELATED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Kapelushnik et al., "MATCHED UNRELATED HUMAN UMBILICAL-CORD BLOOD TRANSPLANTATION FOR X-LINKED ADRENOLEUKODYSTROPHY", Journal of pediatric hematology/oncology, 20(3), 1998, pp. 257-259

Abstract

Purpose: This report evaluates engraftment, immunologic reconstitution, and sera very-long-chain fatty acid levels after matched unrelated human umbilical cord blood transplantation (HUCBT) for adrenoleukodystrophy (ALD). Patient and Methods: A child with X-linked ALD underwent matched unrelated HUCBT and administration of granulocyte colony stimulating factor in combination with erythropoietin. Results: Engraftmentwas complete and stable, with 100% chimerism. Natural killer cell numbers and function were normal more than 3 months after HUCBT. T cell numbers normalized more than 9 months after HUCBT but T cell mitogenic response remained subnormal. Thirteen months after transplantation, the child is in very good clinical condition with normalization of his sera very-long-chain fatty acid levels. Conclusion: Unrelated cord blood transplantation may provide a good source of stem cells for patientswith ALD when a matched sibling is not available

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Documento generato il 08/07/20 alle ore 07:45:43