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Titolo:
ENDOTHELIN-1-(1-31), A NOVEL VASOACTIVE PEPTIDE, INCREASES [CA2-ARTERY SMOOTH-MUSCLE CELLS(](I) IN HUMAN CORONARY)
Autore:
YOSHIZUMI M; INUI D; OKISHIMA N; HOUCHI H; TSUCHIYA K; WAKABAYASHI H; KIDO H; TAMAKI T;
Indirizzi:
UNIV TOKUSHIMA,SCH MED,DEPT PHARMACOL,3-18-15 KURAMOTO TOKUSHIMA 7708503 JAPAN UNIV TOKUSHIMA,INST ENZYME RES,DIV ENZYME CHEM TOKUSHIMA 7708503 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 348, anno: 1998,
pagine: 305 - 309
SICI:
0014-2999(1998)348:2-3<305:EANVPI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIG ENDOTHELIN-1; VASOCONSTRICTOR PEPTIDE; ANGIOTENSIN-II; POTENT; RECEPTOR; METALLOPROTEINASES; ACTIVATION; CONVERSION; CHYMASE;
Keywords:
ENDOTHELIN-1; ENDOTHELIN-1-(1-31); CHYMASE, HUMAN; MICROSCOPY, CONFOCAL; CORONARY ARTERY SMOOTH MUSCLE CELL, HUMAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Yoshizumi et al., "ENDOTHELIN-1-(1-31), A NOVEL VASOACTIVE PEPTIDE, INCREASES [CA2-ARTERY SMOOTH-MUSCLE CELLS(](I) IN HUMAN CORONARY)", European journal of pharmacology, 348(2-3), 1998, pp. 305-309

Abstract

We have previously found that human chymase cleaves big endothelins at the Tyr(31)-Gly(32) bond and produces 31-amino acid long endothelins-(1-31), without any further degradation products. In this study, we investigated the effect of synthetic endothelin-1-(1-31) on the intracellular free Ca2+ concentration([Ca2+](i)) in cultured human coronary artery smooth muscle cells. Endothelin-1-(1-31) increased [Ca2+](i) in a concentration-dependent manner (10(-14) to 10(-10) M), This endothelin-1-(1-31)-induced [Ca2+](i) increase was not affected by phosphoramidon nosyloxyhydroxyphosphinyl)-L-Leucyl-L-Tryptophan), an inhibitor ofendothelin-converting en zyme. It was, however, inhibited by 10(-10) M BQ123 (Cyclo-(-D-Trp-D-Asp(ONa)-Pro-D-Val-Leu-)) endothelin ETA receptor antagonist, but not by 10(-10) M BQ788 (N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma MeLeu-D-Trp(COOMe)-D-Nle-ONa), an endothelin ETB receptor antagonist. These results suggest that endothelin-1-(1-31) by itself exhibits vasoactive properties probably through endothelin ETA receptors. Since human chymase has been reported to play a role in atherosclerosis, endothelin-1-(1-31) may be one of the candidate substances for its cause. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:45:35