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Titolo:
TACHYKININ NK1 RECEPTOR ANTAGONISTS ENHANCE STRESS-INDUCED C-FOS IN RAT LOCUS-COERULEUS
Autore:
HAHN MK; BANNON MJ;
Indirizzi:
WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,2309 SCOTT HALL,540 E CANFIELDDETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT DETROIT MI 48201 WAYNE STATE UNIV,SCH MED,DEPT BEHAV NEUROSCI & PHARMACOL DETROIT MI 48201
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 348, anno: 1998,
pagine: 155 - 160
SICI:
0014-2999(1998)348:2-3<155:TNRAES>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CORTICOTROPIN-RELEASING FACTOR; SUBSTANCE-P; BINDING-SITES; BRAIN-STEM; AUTORADIOGRAPHIC DISTRIBUTION; CATECHOLAMINERGIC NEURONS; NORADRENERGIC NEURONS; GENE-EXPRESSION; NK-1 RECEPTOR;
Keywords:
LOCUS COERULEUS; TACHYKININ NK1 RECEPTOR; NEUROKININ RECEPTOR; SUBSTANCE P; C-FOS; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.K. Hahn e M.J. Bannon, "TACHYKININ NK1 RECEPTOR ANTAGONISTS ENHANCE STRESS-INDUCED C-FOS IN RAT LOCUS-COERULEUS", European journal of pharmacology, 348(2-3), 1998, pp. 155-160

Abstract

These experiments tested the hypothesis that substance P neurotransmission at tachykinin NK1 receptors in the locus coeruleus is involved in stress-induced activation of the locus coeruleus, using c-Sos as an index of activation. Selective tachykinin NK1 receptor antagonists administered systemically did not result in substantial locus coeruleus c-fos expression. Restraint stress resulted in a large number of locus coeruleus c-Sos expressing cells. Administration of two selective tachykinin NK1 receptor antagonists prior to restraint resulted in an increase in the number of locus coeruleus c-Sos expressing cells, comparedto restraint alone. These results suggest that the enhanced c-Sos expression observed in response to tachykinin NK( )1 receptor antagonistscombined with stress, could be due to the blockade of tachykinin NK1 receptor-mediated activity at sites other than the locus coeruleus, resulting in an overall activation of the locus coeruleus. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:19:01