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Titolo:
DNA ALTERATIONS IN RAT ORGANS AFTER CHRONIC EXPOSURE TO CIGARETTE-SMOKE AND OR ETHANOL INGESTION/
Autore:
IZZOTTI A; BALANSKY RM; BLAGOEVA PM; MIRCHEVA ZI; TULIMIERO L; CARTIGLIA C; DEFLORA S;
Indirizzi:
UNIV GENOA,INST HYG & PREVENT MED,VIA PASTORE 1 I-16132 GENOA ITALY UNIV GENOA,INST HYG & PREVENT MED I-16132 GENOA ITALY NATL ONCOL CTR SOFIA 1756 BULGARIA
Titolo Testata:
The FASEB journal
fascicolo: 9, volume: 12, anno: 1998,
pagine: 753 - 758
SICI:
0892-6638(1998)12:9<753:DAIROA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ACETYLCYSTEINE; TOBACCO-SMOKE; P-32-POSTLABELING ANALYSIS; ALVEOLAR MACROPHAGES; ALCOHOL-CONSUMPTION; ADDUCTS; DAMAGE; LUNG; CARCINOGENS; CANCER;
Keywords:
ALCOHOL; SYNERGISMS; DNA ADDUCTS; LUNG CANCER; ESOPHAGEAL CANCER; HEART DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A. Izzotti et al., "DNA ALTERATIONS IN RAT ORGANS AFTER CHRONIC EXPOSURE TO CIGARETTE-SMOKE AND OR ETHANOL INGESTION/", The FASEB journal, 12(9), 1998, pp. 753-758

Abstract

In spite of the epidemiological evidence supporting a synergism between alcohol consumption and cigarette smoking in the pathogenesis of cancers of the aerodigestive tract, there is a paucity of experimental studies evaluating the effects of these agents under well-controlled conditions and exploring the mechanisms involved. We exposed groups of female BD6 rats, aged 8 months, to ethanol (5% in drinking water for 8 consecutive months) and/or whole-body to mainstream cigarette smoke (1h/day, 5 days/week for 8 months). DNA was purified from different organs and analyzed for the presence of DNA-protein crosslinks and P-32-postlabeled DNA adducts after butanol enrichment. No significant increase of DNA-protein crosslinks, compared to untreated controls, was induced by any treatment in liver, lung, or heart. 'Spontaneous' nucleotidic modifications were detected by P-32-postlabeling in organs of untreated rats, with the highest levels occurring in the heart. Ingestion of ethanol did not affect DNA adduct levels in any of the organs examined: esophagus, liver, lung, and heart. Exposure to cigarette smoke induced formation of DNA adducts in the lung and heart, but not in the esophagus or liver. The combined ingestion of ethanol resulted in a significant formation of smoke-related DNA adducts in the esophagus and intheir further, dramatic increase in the heart. It thus appears that ethanol consumption increases the bioavailability of DNA binding smoke components in the upper digestive tract and favors their systemic distribution. The mechanisms responsible for the interaction between ethanol and smoke and for the selective localization of DNA alterations in different organs are discussed. Formation of DNA adducts in the organsexamined may be relevant in the pathogenesis of lung and esophageal cancers as well as in the pathogenesis of other types of chronic degenerative diseases, such as chronic obstructive pulmonary diseases and cardiomyopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:43:23