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Titolo:
EXPRESSION OF NGF RECEPTORS IN NORMAL AND PATHOLOGICAL HUMAN THYMUS
Autore:
PARRENS M; LABOUYRIE E; GROPPI A; DUBUS P; CARLES D; VELLY JF; DEMASCAREL A; MERLIO JP;
Indirizzi:
UNIV BORDEAUX 2,UFR 3,LAB HISTOL EMBRYOL,146 RUE LEO SAIGNAT F-33076 BORDEAUX FRANCE CHU BORDEAUX,SERV ANAT PATHOL,UFR 3,LAB HISTOL EMBRYOL F-33076 BORDEAUX FRANCE HOP PELLEGRIN,SERV ANAT PATHOL F-33076 BORDEAUX FRANCE CHU BORDEAUX,HOP HAUT LEVEQUE,SERV CHIRURG THORAC F-33064 PESSAC FRANCE
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1, volume: 85, anno: 1998,
pagine: 11 - 21
SICI:
0165-5728(1998)85:1<11:EONRIN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; TYROSINE PROTEIN-KINASE; TRK PROTOONCOGENE PRODUCT; NEUROTROPHIN RECEPTOR; MONOCLONAL-ANTIBODIES; NEURAL CREST; CELLS; LOCALIZATION; FAMILY; TISSUES;
Keywords:
P75(NGFR); TRK; NERVE GROWTH FACTOR; THYMUS; THYMOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M. Parrens et al., "EXPRESSION OF NGF RECEPTORS IN NORMAL AND PATHOLOGICAL HUMAN THYMUS", Journal of neuroimmunology, 85(1), 1998, pp. 11-21

Abstract

The expression of NGF receptors was investigated in normal human thymus and in thymic hyperplasias, thymomas and thymic carcinomas. By RT-PCR, we detected TrkAI transcripts encoding for the high-affinity NGF receptor. Western blot analysis showed the presence of both TrkA and p75(NGFR) proteins. In normal thymuses, epithelial subcapsular and medullar cells were TrkA immunoreactive. Interdigitated medullar cells werestained for both TrkA and p75(NGFR). While epithelial cells of normalthymuses or benign thymomas exhibited a TrkA positive-p75(NGFR) negative phenotype, a switch to a TrkA negative-p75(NGFR) positive phenotype was observed in malignant epithelial cell tumours and was associatedwith cell proliferation-associated MIB1 expression. Our results arguefor a local role of NGF and its receptors on thymic stromal cells both in normal and neoplastic conditions. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:13:58