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Titolo:
2 IMMUNOGLOBULIN-LIKE DOMAINS OF THE Z-DISC PORTION OF TITIN INTERACTIN A CONFORMATION-DEPENDENT WAY WITH TELETHONIN
Autore:
MUES A; VANDERVEN PFM; YOUNG P; FURST DO; GAUTEL M;
Indirizzi:
EUROPEAN MOL BIOL LAB,STRUCT BIOL DIV,MEYERHOFSTR 1 D-69117 HEIDELBERG GERMANY EUROPEAN MOL BIOL LAB,STRUCT BIOL DIV D-69117 HEIDELBERG GERMANY UNIV POTSDAM,DEPT CELL BIOL D-14471 POTSDAM GERMANY
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 428, anno: 1998,
pagine: 111 - 114
SICI:
0014-5793(1998)428:1-2<111:2IDOTZ>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE; PROTEINS; DIFFERENTIATION; FILAMENTS; MAP;
Keywords:
TITIN; CONNECTIN; TELETHONIN; Z-DISK; MYOFIBRILLOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A. Mues et al., "2 IMMUNOGLOBULIN-LIKE DOMAINS OF THE Z-DISC PORTION OF TITIN INTERACTIN A CONFORMATION-DEPENDENT WAY WITH TELETHONIN", FEBS letters, 428(1-2), 1998, pp. 111-114

Abstract

The giant muscle protein titin/connectin plays a crucial role in myofibrillogenesis as a molecular ruler for sarcomeric protein sorting. Wedescribe here that the N-terminal titin immunoglobulin domains Z1 andZ2 interact specifically with telethonin in yeast two-hybrid analysisand protein binding assays, Immunofluorescence with antibodies against the N-terminal region of titin and telethonin detects both proteins at the Z-disc of human myotubes. Longer titin fragments, comprising a serine-proline-rich phosphorylation site and the nest domain, do not interact. The interaction of telethonin with titin is therefore conformation-dependent, reflecting a possible phosphorylation regulation during myofibrillogenesis. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:45:51