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Titolo:
IMPAIRED MYOCARDIAL VASODILATION DURING HYPEREMIC STRESS WITH DIPYRIDAMOLE IN HYPERTRIGLYCERIDEMIA
Autore:
YOKOYAMA I; OHTAKE T; MOMOMURA S; YONEKURA K; NISHIKAWA J; SASAKI Y; OMATA M;
Indirizzi:
UNIV TOKYO,DEPT INTERNAL MED 2,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,DEPT RADIOL TOKYO 113 JAPAN
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 7, volume: 31, anno: 1998,
pagine: 1568 - 1574
SICI:
0735-1097(1998)31:7<1568:IMVDHS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; BLOOD-FLOW; N-13 AMMONIA; PLASMA TRIGLYCERIDES; INSULIN RESISTANCE; ENDOGENOUS HYPERTRIGLYCERIDEMIA; FAMILIAL HYPERCHOLESTEROLEMIA; HYPERTROPHIC CARDIOMYOPATHY; INTRAVENOUS DIPYRIDAMOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
I. Yokoyama et al., "IMPAIRED MYOCARDIAL VASODILATION DURING HYPEREMIC STRESS WITH DIPYRIDAMOLE IN HYPERTRIGLYCERIDEMIA", Journal of the American College of Cardiology, 31(7), 1998, pp. 1568-1574

Abstract

Objectives. This study sought to investigate the specific sole of hypertriglyceridemia in the myocardial hyperemic stress with dipyridamole/rest flow ratio (MDR). Background. Reduced MDR has beers reported in hypercholesterolemic patients without evidence of ischemia. However, the specific role of hypertriglyceridemia in MDR has not been studied. Methods. Fifteen nondiabetit normocholesterolemic hypertriglyceridemicpatients and 13 age-matched control subjects were studied. Myocardialblood flow (MBF) during dipyridamole administration and baseline MBF in hypertriglyceridemic patients and control subjects were measured using positron emission tomography and nitrogen-13 ammonia, after which the MDR was calculated. Results. Baseline MBF (ml/min per 100 g heart weight) in hypertriglyceridemic patients (mean +/- SD 73.6 +/- 24.1) did not differ significantly from that in control subjects (81.6 +/- 37.2). MBF during dipyridamole loading in hypertriglyceridemic patients (198 +/- 106) was significantly reduced compared with that in control subjects (313 +/- 176, p < 0.05), as was the MDR (2.71 +/- 1.07 vs. 3.73 1.14, respectively, g < 0.05). Spearman rank-order correlation analysis showed a significant relation between plasma triglyceride concentration and MDR (r = -0.466, asymptotic SE 0.157, p = 0.0125); however,no such significant relation mas seen between total plasma cholesterol concentration and MDR (r = -0.369, asymptotic SE 0.130, p = 0.059). Conclusions. Impaired myocardial vasodilation was suggested in hypertriglyceridemic patients without symptoms and signs of ischemia.

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Documento generato il 22/01/20 alle ore 09:23:29