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Titolo:
VITAMIN-E, LIPIDS, AND LIPID-PEROXIDATION PRODUCTS IN TARDIVE-DYSKINESIA
Autore:
BROWN K; REID A; WHITE T; HENDERSON T; HUKIN S; JOHNSTONE C; GLEN A;
Indirizzi:
CENT SCOTLAND HEALTHCARE NHS TRUST LARBERT FK5 4SF SCOTLAND BELLSDYKE HOSP,CENT SCOTLAND HEALTHCARE NHS TRUST LARBERT SCOTLAND VICTORIA INFIRM,NHS TRUST,DEPT BIOCHEM GLASGOW LANARK SCOTLAND STATE HOSP CARSTAIRS SCOTLAND
Titolo Testata:
Biological psychiatry
fascicolo: 12, volume: 43, anno: 1998,
pagine: 863 - 867
SICI:
0006-3223(1998)43:12<863:VLALPI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; TOCOPHEROL; PLASMA; INDEXES;
Keywords:
TARDIVE DYSKINESIA; SCHIZOPHRENIA; VITAMIN-E; LIPID PEROXIDATION; FREE RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Brown et al., "VITAMIN-E, LIPIDS, AND LIPID-PEROXIDATION PRODUCTS IN TARDIVE-DYSKINESIA", Biological psychiatry, 43(12), 1998, pp. 863-867

Abstract

Background: Lipid peroxidation has been postulated as a possible mechanism for neuronal damage in tardive dyskinesia, and this Is supportedby evidence of increased lipid peroxidation products in the cerebrospinal fluid of dyskinetic subjects. Methods: In this study plasma levels of vitamin E and vitamin A, measured by high-performance liquid chromatography and of thiobarbituric acid-reactive substances (TBARS), were determined in 16 schizophrenic patients with tardive dyskinesia, 16 nondyskinetic patients all assessed by Abnormal Involuntary Movement Scale (AIMS)! and 10 normal control subjects. Plasma cholesterol and triglyceride were also measured through out. Vitamin E levels in plasma Mere corrected for total lipids. Results: Multivariate analysis of covariance showed significant differences when vitamin E and TBARS were compared in the three groups, Univariate t tests showed a significantlylower lipid-corrected vitamin E (p =.018) between the normal and dyskinetic group but not between the normal and the nondyskinetic schizophrenic patients. There was no difference in vitamin A levels between patients and normal controls, TBAR results showed a significant positivecorrelation between AIMS score and lipid-corrected TBARS. Conclusions: This study confirms an abnormality associating lipid peroxidation and tardive dyskinesia and extends this abnormality to measurements of lipid-corrected vitamin E in plasma. (C) 1998 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:19:50