Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRESENCE AND CHARACTERIZATION OF THE SEROTONIN TRANSPORTER IN HUMAN RESTING LYMPHOCYTES
Autore:
MARAZZITI D; ROSSI A; GIANNACCINI G; BARONI S; LUCACCHINI A; CASSANO GB;
Indirizzi:
UNIV PISA,DIPARTIMENTO PSICHIATRIA NEUROBIOL FARMACOL & BIO,VIA ROMA 67 I-56100 PISA ITALY
Titolo Testata:
Neuropsychopharmacology
fascicolo: 2, volume: 19, anno: 1998,
pagine: 154 - 159
SICI:
0893-133X(1998)19:2<154:PACOTS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; HIGH-AFFINITY BINDING; HUMAN-PLATELETS; UPTAKE SITES; PANIC DISORDER; HUMAN-BRAIN; )H-3>IMIPRAMINE; IMIPRAMINE; EXPRESSION; INHIBITOR;
Keywords:
SEROTONIN; SEROTONIN TRANSPORTER; HUMAN LYMPHOCYTES; PHARMACOLOGICAL CHARACTERIZATION; ANTIDEPRESSANTS; SSRIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D. Marazziti et al., "PRESENCE AND CHARACTERIZATION OF THE SEROTONIN TRANSPORTER IN HUMAN RESTING LYMPHOCYTES", Neuropsychopharmacology, 19(2), 1998, pp. 154-159

Abstract

Although evidence exists of the presence of serotonin (5-HT) reuptakesystem in lymphocytes, no information is available on the pharmacological characterization of this structure. Our study aimed to investigate this matter, therefore, by means of the binding of [H-3]-paroxetine ([H-3]PAR), a selective 5-HT reuptake inhibitor (SSRI), which is considered the ligand of choice for binding studies. Lymphocytes were obtained from a pool of 20 healthy subjects who volunteered for the study. The results showed the presence of a specific and saturable [H-3]PAR binding to lymphocyte membranes, with a Hill number close to unity indicative of the presence of one site only. The most potent drugs inhibiting [H-3]PAR binding were SSRIs (paroxetine, fluoxetine, citalopram) followed by clomipramine, imipramine, and 5-HT, whereas haloperidol, mazindol, and nomifensine had a negligible effect. These findings suggest that [H-3]-PAR in human resting lymphocytes specifically labels the 5-HT transporter. (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:45:29