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Titolo:
SUSTAINED WITHDRAWAL ALLOWS NORMALIZATION OF IN-VIVO [C-11] N-METHYLSPIPERONE DOPAMINE D-2 RECEPTOR-BINDING AFTER CHRONIC BINGE COCAINE - APOSITRON-EMISSION-TOMOGRAPHY STUDY IN RATS
Autore:
MAGGOS CE; TSUKADA H; KAKIUCHI T; NISHIYAMA S; MYERS JE; KREUTER J; SCHLUSSMAN SD; UNTERWALD EM; HO A; KREEK MJ;
Indirizzi:
ROCKEFELLER UNIV,LAB BIOL ADDICT DIS,1230 YORK AVE BOX 171 NEW YORK NY 10021 ROCKEFELLER UNIV,LAB BIOL ADDICT DIS NEW YORK NY 10021 HAMAMATSU PHOTON KK,CENT RES LAB SHIZUOKA 434 JAPAN NYU,MED CTR,DEPT PSYCHIAT NEW YORK NY 10016
Titolo Testata:
Neuropsychopharmacology
fascicolo: 2, volume: 19, anno: 1998,
pagine: 146 - 153
SICI:
0893-133X(1998)19:2<146:SWANOI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; MICRODIALYSIS; BRAIN; ASSAY;
Keywords:
COCAINE; DOPAMINE RECEPTORS; [C-11] SCH23390; [C-11] N-METHYLSPIPERONE; POSITRON EMISSION TOMOGRAPHY; RAT BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Maggos et al., "SUSTAINED WITHDRAWAL ALLOWS NORMALIZATION OF IN-VIVO [C-11] N-METHYLSPIPERONE DOPAMINE D-2 RECEPTOR-BINDING AFTER CHRONIC BINGE COCAINE - APOSITRON-EMISSION-TOMOGRAPHY STUDY IN RATS", Neuropsychopharmacology, 19(2), 1998, pp. 146-153

Abstract

In our previous positron emission tomography studies striatal bindingfor both [C-11]SCH23390 and [C-11]N-methylspiperone (NMSP) were decreased in the rat brain on the last day of chronic (14 days) binge cocaine administration. We have found that [C-11]SCH23390 binding to dopamine D-1 receptors returns to saline control levels within ten days withdrawal from chronic binge cocaine and remains at control levels after 21 days withdrawal. An 18% decrease in [C-11]NMSP binding to dopamine D-2 receptors was observed after ten days withdrawal. However, importantly, after 21 days withdrawal [C-11]NMSP binding was at saline control levels. Changes of in vivo [C-11]NMSP binding required a longer abstinence period for normalization than [C-11]SCH23390 binding. The apparent recovery of dopamine D-2 receptors after prolonged abstinence fromchronic cocaine and the different rates of normalization for dopamineD-1 versus D-2 receptors may be critical information for development of pharmacotherapies for cocaine dependent patients. (C) 1998 AmericanCollege of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:29:31