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Titolo:
IDENTIFICATION AND LOCALIZATION OF TYPE-IV COLLAGEN CHAINS IN THE INNER-EAR COCHLEA
Autore:
KALLURI R; GATTONE VH; HUDSON BG;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT BIOCHEM MOL BIOL & ANAT & CELL BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM MOL BIOL & ANAT & CELL BIOL KANSAS CITY KS 66160 UNIV PENN,DEPT MED,PENN CTR MOL STUDIES KIDNEY DIS,RENAL ELECTROLYTE & HYPERTENS DIV PHILADELPHIA PA 19104
Titolo Testata:
Connective tissue research
fascicolo: 1-2, volume: 37, anno: 1998,
pagine: 143 - 150
SICI:
0300-8207(1998)37:1-2<143:IALOTC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE COLLAGEN; NONCOLLAGENOUS DOMAIN HEXAMER; GOODPASTURE-SYNDROME; ALPHA-3(IV) CHAIN; ALPORT SYNDROME; MURINE COCHLEA; ANTIGEN; AUTOANTIBODIES; AUTOANTIGEN; TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Kalluri et al., "IDENTIFICATION AND LOCALIZATION OF TYPE-IV COLLAGEN CHAINS IN THE INNER-EAR COCHLEA", Connective tissue research, 37(1-2), 1998, pp. 143-150

Abstract

Mutations in the genes encoding the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of type IV collagen have been implicated in the pathogenesis of Alport's syndrome, a hereditary disorder characterized by progressive nephropathy and sensorineural deafness. The known expression of these chains in kidney basement membranes supports the contention that they play a crucial role in the ultrafiltration function. Whether they play a role in auditory signal transduction remains unknown as heretofore, they have not been identified in the inner ear. In the present study, the expression of type IV collagen in cochlea of the inner ear of guinea pigs was determined. All six alpha-chains of type IV collagen were identified by biochemical and immunological methods. By indirect immunofluorescence, alpha 1(IV) and alpha 2(IV) chains were localized to the spiral limbus, basilar membrane and tectorial membrane, The alpha 3(IV), alpha 4(IV), alpha 5(IV) and alpha 6(IV) chains localized exclusively to the tectorial membrane and basilar membrane. These results suggest a possible role of type IV collagen chains in the active tuning of the basilar and tectorial membrane, an essential step in frequency discrimination and amplification of auditory signals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:09:03