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Titolo:
THYMOPENTIN AND SPLENOPENTIN AS IMMUNOMODULATORS - CURRENT STATUS
Autore:
SINGH VK; BISWAS S; MATHUR KB; HAQ W; GARG SK; AGARWAL SS;
Indirizzi:
SANJAY GANDHI POSTGRAD INST MED SCI,DEPT IMMUNOL,LAB MOL IMMUNOL LUCKNOW 226014 UTTAR PRADESH INDIA CENT DRUG RES INST,DIV BIOPOLYMERS LUCKNOW 226001 UTTAR PRADESH INDIA RML AWADH UNIV,DEPT MICROBIOL FAIZABAD UTTAR PRADESH INDIA
Titolo Testata:
Immunologic research
fascicolo: 3, volume: 17, anno: 1998,
pagine: 345 - 368
SICI:
0257-277X(1998)17:3<345:TASAI->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMOPOIETIN PENTAPEPTIDE TP-5; NATURAL-KILLER ACTIVITY; INVIVO IMMUNOPOTENTIATING ACTIVITY; THYMIC HORMONE THYMOPOIETIN; BONE-MARROW TRANSPLANTATION; COLONY-STIMULATING FACTOR; ANTIGEN-INDUCED ARTHRITIS; T-CELL-DIFFERENTIATION; HIV-INFECTED SUBJECTS; AMINO-ACID-SEQUENCE;
Keywords:
IMMUNOMODULATION; SPLENIN; SPLENOPENTIN; THYMOPOIETIN; THYMOPENTIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
146
Recensione:
Indirizzi per estratti:
Citazione:
V.K. Singh et al., "THYMOPENTIN AND SPLENOPENTIN AS IMMUNOMODULATORS - CURRENT STATUS", Immunologic research, 17(3), 1998, pp. 345-368

Abstract

Splenopentin (SP-5, Arg-Lys-Glu-Val-Tyr) and thymopentin (TP-5, Arg-Lys-Asp-Val-Tyr) are synthetic immunomodulating peptides corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. TP was originally isolated as a 5-kDa (49-amino acids) protein from bovine thymus while studying effects of the thymic extracts on neuromuscular transmission and was subsequently observed to affect T cell differentiation and function. TP I and II are two closely related polypeptides isolated from bovine thymus. A radioimmunoassay for TP revealed a crossreaction with a product found in spleen and lymph node. This product, named splenin, differs from TP only in position 34, aspartic acid for bovine TP and glutamic acid for bovine splenin and it was called TP III as well. Synthetic pentapeptides (TP-5) and (SP-5), reproduce the biological activities of TP and SP, respectively. It is now evident that various forms of TPs were created by proteolytic cleavage of larger proteins during isolation. cDNA clones have been isolated for three alternatively splicedmRNAs that encodes three distinct human T cell TPs. The immunomodulatory properties of TP, SP, TP-5, SP-5 and some of their synthetic analogs reported in the literature have been briefly reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:56:37