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Titolo:
THE A1 ALLELE OF THE HUMAN D-2 DOPAMINE-RECEPTOR GENE PREDICTS LOW D-2 RECEPTOR AVAILABILITY IN HEALTHY-VOLUNTEERS
Autore:
POHJALAINEN T; RINNE JO; NAGREN K; LEHIKOINEN P; ANTTILA K; SYVALAHTI EKG; HIETALA J;
Indirizzi:
TURKU UNIV,CENT HOSP,DEPT PSYCHIAT 721 TURKU 20520 FINLAND TURKU UNIV,CENT HOSP,DEPT PSYCHIAT 721 TURKU 20520 FINLAND TURKU UNIV,DEPT PHARMACOL & CLIN PHARMACOL TURKU 20520 FINLAND TURKU UNIV,CENT HOSP,DEPT NEUROL TURKU 20520 FINLAND
Titolo Testata:
Molecular psychiatry
fascicolo: 3, volume: 3, anno: 1998,
pagine: 256 - 260
SICI:
1359-4184(1998)3:3<256:TAAOTH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 RACLOPRIDE; BINDING CHARACTERISTICS; PROMOTER REGION; STRIATAL D-2; ALCOHOLISM; PET; ASSOCIATION; DENSITY;
Keywords:
DRD2; POLYMORPHISM; ASSOCIATION; TAQIA RFLP; PET; RECEPTOR BINDING; [C-11] RACLOPRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Pohjalainen et al., "THE A1 ALLELE OF THE HUMAN D-2 DOPAMINE-RECEPTOR GENE PREDICTS LOW D-2 RECEPTOR AVAILABILITY IN HEALTHY-VOLUNTEERS", Molecular psychiatry, 3(3), 1998, pp. 256-260

Abstract

Positron emission tomography (PET) studies have revealed significant interindividual variation in dopamine D-2 receptor density in vivo in human striatum.(1) Low D-2 receptor binding in vivo has been found to associate with alcohol/substance dependence,(2-6) It has been suggested that the Al allele of human D-2 receptor gene might be associated toa specific type of alcoholism(7) and possibly to a reduced D-2 receptor density in vitro.(8) We have determined D-2 dopamine receptor-binding density (B-max), affinity (K-d) and availability (B-max/K-d) in 54 healthy Finnish volunteers using PET and [C-11]raclopride in order to determine whether the A1 allele is associated with a 'baseline' difference in D-2 receptor characteristics in vivo. A statistically significant reduction in D-2 receptor availability reflecting an alteration inreceptor density was observed in the A1/A2 genotype group compared tothe A2/A2 group. There was no difference in apparent K-d between the two groups. In conclusion, the association between the A1 allele and low D-2 receptor availability in healthy subjects indicates that the A1allele of the TaqIA polymorphism might be in linkage disequilibrium with a mutation in the promoter/regulatory gene element that affects dopamine D-2 receptor expression. This study provides an in vivo neurobiological correlate to the A1 allele in healthy volunteers.

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Documento generato il 09/04/20 alle ore 10:45:14