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Titolo:
EVALUATION OF THE ANTIMICROBIAL EFFECT OF LACTOFERRIN ON PORPHYROMONAS-GINGIVALIS, PREVOTELLA-INTERMEDIA AND PREVOTELLA-NIGRESCENS
Autore:
AGUILERA O; ANDRES MT; HEATH J; FIERRO JF; DOUGLAS CWI;
Indirizzi:
UNIV SHEFFIELD,SCH CLIN DENT,DEPT ORAL PATHOL,CLAREMONT CRESCENT SHEFFIELD S10 2TA S YORKSHIRE ENGLAND UNIV SHEFFIELD,SCH CLIN DENT,DEPT ORAL PATHOL SHEFFIELD S10 2TA S YORKSHIRE ENGLAND UNIV OVIEDO,FAC MED,DEPT BIOL FINCT,AREA MICROBIOL,SCH STOMATOL,LAB ORAL MICROBIOL E-33006 OVIEDO SPAIN
Titolo Testata:
FEMS immunology and medical microbiology
fascicolo: 1, volume: 21, anno: 1998,
pagine: 29 - 36
SICI:
0928-8244(1998)21:1<29:EOTAEO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; HEMIN; DEGRADATION; LYSOZYME; BACTERIA; W50;
Keywords:
LACTOFERRIN; HEMIN; PORPHYROMONAS GINGIVALIS; PREVOTELLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
O. Aguilera et al., "EVALUATION OF THE ANTIMICROBIAL EFFECT OF LACTOFERRIN ON PORPHYROMONAS-GINGIVALIS, PREVOTELLA-INTERMEDIA AND PREVOTELLA-NIGRESCENS", FEMS immunology and medical microbiology, 21(1), 1998, pp. 29-36

Abstract

The antimicrobial effect of lactoferrin (apoLf) on the oral, black-pigmented anaerobes Porphyromonas gingivalis, Prevotella intermedia and P. nigrescens has been studied. ApoLf did not kill any of these species but it did inhibit the growth of P. gingivalis, while iron-saturatedLf (FeLf) had no effect. The other two species were unaffected by apoLf. This growth inhibitory effect of apoLf could not be explained on the basis of chelation of inorganic iron, since growth of P. gingivalisoccurred in the presence of ethylenediamine di-o-hydroxyphenylacetic acid provided haemin was added. Both apoLf and FeLf reduced haemin uptake by all three species and caused the release of cell-bound haemin in a dose-dependent manner. In addition, haemin reduced the binding of both apoLf and FeLf to P. intermedia and P. nigrescens but stimulated the binding of Lf by P. gingivalis. These data suggest that Lf forms complexes with haemin in solution and competes for the binding of haemin to certain cell receptors, possibly lipopolysaccharides, but this isnot sufficient to inhibit growth of the bacteria. P. gingivalis appears to bind Lf-haemin complexes, as well as haemin alone, which may facilitate access of the Lf to the outer and cytoplasmic membranes of P. gingivalis, so disrupting function. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:26:47