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Titolo:
EMBIGIN BASIGIN SUBGROUP OF THE IMMUNOGLOBULIN SUPERFAMILY - DIFFERENT MODES OF EXPRESSION DURING MOUSE EMBRYOGENESIS AND CORRELATED EXPRESSION WITH CARBOHYDRATE ANTIGENIC MARKERS/
Autore:
FAN QW; KADOMATSU K; UCHIMURA K; MURAMATSU T;
Indirizzi:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,SHOWA KU,65 TSURUMAI CHO NAGOYA AICHI 466 JAPAN NAGOYA UNIV,SCH MED,DEPT BIOCHEM,SHOWA KU NAGOYA AICHI 466 JAPAN
Titolo Testata:
Development, growth & differentiation
fascicolo: 3, volume: 40, anno: 1998,
pagine: 277 - 286
SICI:
0012-1592(1998)40:3<277:EBSOTI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONAL CARCINOMA-CELLS; BLOOD-BRAIN-BARRIER; DEVELOPMENTALLY REGULATED EXPRESSION; DOLICHOS-BIFLORUS AGGLUTININ; IMMUNOHISTOCHEMICAL LOCALIZATION; SURFACE GLYCOPROTEIN; SUBSTRATUM ADHESION; MEMBER; BASIGIN; RECOGNITION;
Keywords:
BASIGIN; CARBOHYDRATE ANTIGENS; EMBIGIN; FUCOSYL-TRANSFERASE; MOUSE EMBRYOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Q.W. Fan et al., "EMBIGIN BASIGIN SUBGROUP OF THE IMMUNOGLOBULIN SUPERFAMILY - DIFFERENT MODES OF EXPRESSION DURING MOUSE EMBRYOGENESIS AND CORRELATED EXPRESSION WITH CARBOHYDRATE ANTIGENIC MARKERS/", Development, growth & differentiation, 40(3), 1998, pp. 277-286

Abstract

Embigin and basigin are highly glycosylated transmembrane glycoproteins with two immunoglobulin domains and form a subgroup in the immunoglobulin superfamily. Previous studies have demonstrated the functional significance of these molecules. In the present study, in situ hybridization analysis of their expression was performed during mouse embryogenesis. Embigin was strongly expressed in the endoderm during early postimplantation embryogenesis, and in the somite stage in the gut and visceral endoderm. Embryonic ectoderm and its derivative tissues weaklyto moderately expressed this molecule. From day 10 to 15 of gestation, no embigin signal was detected. Basigin was more broadly expressed. During the organogenesis period, basigin was expressed in various epithelial tissues, brain ventricles, the spinal cord and dorsal root ganglion. The modes of expression of these two proteins throughout the eggcylinder stage correlated with the expression of the carbohydrate markers that they carry; embigin with Dolichos biflorus agglutinin binding sites and basigin with Le(x) antigen and more closely with fucosyltransferase IV, which forms the antigenic epitope. These findings imply that proteins with specific carbohydrate epitopes play roles in early postimplantation embryogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:26:25