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Titolo:
STRUCTURE AND EXPRESSION OF THE ORPHAN NUCLEAR RECEPTOR SHP GENE
Autore:
LEE HK; LEE YK; PARK SH; KIM YS; PARK SH; LEE JW; KWON HB; SOH J; MOORE DD; CHOI HS;
Indirizzi:
CHONNAM NATL UNIV,HORMONE RES CTR KWANGJU 500757 SOUTH KOREA CHONNAM NATL UNIV,DEPT BIOL KWANGJU 500757 SOUTH KOREA CHONNAM NATL UNIV,COLL PHARM KWANGJU 500757 SOUTH KOREA BAYLOR COLL MED,DEPT CELL BIOL HOUSTON TX 77030 KOREA UNIV,COLL MED,DEPT ANAT SEOUL 136750 SOUTH KOREA SEOUL NATL UNIV,COLL MED,DEPT PATHOL SEOUL 110799 SOUTH KOREA CHONNAM NATL UNIV,HORMONE RES CTR KWANGJU 500757 SOUTH KOREA
Titolo Testata:
The Journal of biological chemistry
fascicolo: 23, volume: 273, anno: 1998,
pagine: 14398 - 14402
SICI:
0021-9258(1998)273:23<14398:SAEOTO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE RECEPTOR; SUPERFAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H.K. Lee et al., "STRUCTURE AND EXPRESSION OF THE ORPHAN NUCLEAR RECEPTOR SHP GENE", The Journal of biological chemistry, 273(23), 1998, pp. 14398-14402

Abstract

To determine the organization of the orphan nuclear receptor SHP gene(Seol, W., Choi, H.-S., and Moore, D.D. (1996) Science 272, 1336-1339), genomic clones were isolated from human and mouse genomic Libraries. The SLIP gene was composed of two exons interrupted by a single intron spanning approximately 1.8 kilobases in human and 1.2 kilobases in mouse. Genomic Southern blot analysis and fluorescence in situ hybridization of human metaphase chromosomes indicated that the SRP gene is located at the human chromosome 1p36.1 sub-band. The 5'-flanking regions of human and mouse SHP genes were highly conserved, showing 77% homology in the resell of approximately 600 nucleotides upstream from the transcription start site. Primer extension analysis was carried out todetermine the transcription start site of human SHP to 32 nucleotidesdownstream of a potential TATA box. The human SHP gene was specifically expressed En fetal liver, fetal adrenal gland, adult spleen, and adult small intestine, As expected from this expression pattern, the activity of the mouse SHP promoter measured by transient transfection wassignificantly higher in the adrenal-derived YI cells than HeLa cells.

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Documento generato il 03/12/20 alle ore 21:12:26