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Titolo:
DEVELOPMENTAL-CHANGES IN SUBCELLULAR AMPA GLUR RECEPTOR POPULATIONS IN RAT FOREBRAIN/
Autore:
STANDLEY S; WAGLE N; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM,HEDCO NEUROSCI BLDG LOS ANGELES CA 90089
Titolo Testata:
Developmental brain research
fascicolo: 2, volume: 107, anno: 1998,
pagine: 277 - 283
SICI:
0165-3806(1998)107:2<277:DISAGR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; QUISQUALATE RECEPTORS; HIPPOCAMPAL-FORMATION; SILENT SYNAPSES; ACID AMPA; BINDING; EXPRESSION; LTP; BRAIN; TELENCEPHALON;
Keywords:
GLUTAMATE; AMPA; GLUR; SUBCELLULAR; MATURATION; GLYCOSYLATION; LOCALIZATION; SYNAPTIC PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Standley et al., "DEVELOPMENTAL-CHANGES IN SUBCELLULAR AMPA GLUR RECEPTOR POPULATIONS IN RAT FOREBRAIN/", Developmental brain research, 107(2), 1998, pp. 277-283

Abstract

Forebrains from rats of postnatal days (PND) 2, 7, 14, 21, and 30-40 were subjected to subcellular fractionation and samples from crude mitochondrial (P2, which contain synaptic plasma membranes) and microsomal (P3) fractions were used for SDS-PAGE and Western blotting with antibodies against GluR1, and GluR2/3 subunits of AMPA/GluR receptors. GluR immunoreactivity in P2 fractions increased gradually from PND 2 to PND 30. in contrast, GluR immunoreactivity in P3 fractions increased sharply at early postnatal ages, and was higher than in adults as early as at PND 7. Data were compared to postnatal changes in H-3-AMPA binding reported in various studies. Significant correlations were observedbetween changes in GluR immunoreactivity in P3 fractions and changes in high-affinity binding on one hand and between changes in GluR immunoreactivity in P2 fractions, and changes in low affinity binding. These data further establish that glutamate receptors present in differentsubcellular compartments represent different maturational states of the receptors, and suggest that changes in GluR populations could participate in mechanisms of synaptic plasticity. (C) 1998 Elsevier ScienceB.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:51:10