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Titolo:
EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND OTHER BETA-CHEMOKINES BY RESIDENT GLIA AND INFLAMMATORY CELLS IN MULTIPLE-SCLEROSIS LESIONS
Autore:
SIMPSON JE; NEWCOMBE J; CUZNER ML; WOODROOFE MN;
Indirizzi:
SHEFFIELD HALLAM UNIV,DEPT BIOMED SCI,POND ST,CITY CAMPUS SHEFFIELD S1 1WB S YORKSHIRE ENGLAND SHEFFIELD HALLAM UNIV,DEPT BIOMED SCI SHEFFIELD S1 1WB S YORKSHIRE ENGLAND INST NEUROL,MULTIPLE SCLEROSIS LAB LONDON WC1N 1PJ ENGLAND
Titolo Testata:
Journal of neuroimmunology
fascicolo: 2, volume: 84, anno: 1998,
pagine: 238 - 249
SICI:
0165-5728(1998)84:2<238:EOMCPA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MESSENGER-RNA EXPRESSION; IN-SITU HYBRIDIZATION; CHEMOTACTIC CYTOKINES; DISEASE; FAMILY; RANTES; MCP-1;
Keywords:
CHEMOKINES; MIP-1-ALPHA; MIP-1-BETA; MCP-1; RANTES; INFLAMMATION; MULTIPLE SCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Simpson et al., "EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND OTHER BETA-CHEMOKINES BY RESIDENT GLIA AND INFLAMMATORY CELLS IN MULTIPLE-SCLEROSIS LESIONS", Journal of neuroimmunology, 84(2), 1998, pp. 238-249

Abstract

beta-chemokines induce the directional migration of monocytes and T lymphocytes and are thus associated with chronic inflammation. Using immunocytochemistry and in situ hybridisation (ISH) techniques, we have examined the expression of the beta-chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES (regulated upon activation, normal T cell expressed and secreted) in post-mortem human brain from multiple sclerosis (MS) cases? at different stages of lesion development. In actively demyelinating MS plaques RANTES expression was restricted to the blood vessel endothelium, perivascular cells and surrounding astrocytes, suggesting a role in the recruitment of inflammatory cells from the circulation. MCP-I was expressed by astrocytes and macrophages within acute RISlesions, but was restricted to reactive astrocytes in the parenchyma surrounding the lesion. MIP-1 alpha was expressed by astrocytes and macrophages within the plaque, while MIP-1 beta was expressed by macrophages and microglia within the lesion, and by microglia in surrounding white matter. Glial cells may be stimulated to produce chemokines and continue the local inflammatory response by forming chemotactic gradients to attract T cells and mononuclear phagocytes from the circulationand surrounding tissue. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:58:18