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Titolo:
EFFECT OF LIDOCAINE ON LEFT-VENTRICULAR PRESSURE-VOLUME CURVES DURINGDEMAND ISCHEMIA IN PIGS
Autore:
TAYAMA M; SOLOMON SB; GLANTZ SA;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DIV CARDIOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,DEPT MED SAN FRANCISCO CA 94143
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 43, anno: 1998,
pagine: 2100 - 2109
SICI:
0363-6135(1998)43:6<2100:EOLOLP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PACING-INDUCED ISCHEMIA; RECRUITABLE STROKE WORK; INTRACELLULAR CALCIUM; CONTRACTILE PERFORMANCE; CONDUCTANCE CATHETER; DIASTOLIC FUNCTION; CORONARY STENOSES; RAT-HEART; DOGS; REPERFUSION;
Keywords:
SYSTOLIC FUNCTION; CARDIAC MECHANICS; HEMODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
M. Tayama et al., "EFFECT OF LIDOCAINE ON LEFT-VENTRICULAR PRESSURE-VOLUME CURVES DURINGDEMAND ISCHEMIA IN PIGS", American journal of physiology. Heart and circulatory physiology, 43(6), 1998, pp. 2100-2109

Abstract

The diastolic pressure-volume curve shifts upward during demand ischemia, most likely because of changes in Ca2+ dynamics within the sarcomere. It is possible that agents that affect Na+/Ca2+ exchange, such asLidocaine, a class Ib-type Na+-channel blocker that decreases intracellular Na+, could affect the diastolic pressure-volume relationship because of indirect effects on intracellular Ca2+. Lidocaine is a drug widely used to treat arrhythmias in patients with myocardial ischemia. We studied the effects of Lidocaine on diastolic dysfunction associated with demand ischemia. We compared diastolic las represented by the shift in the diastolic pressure-volume relationship) and systolic function during demand ischemia before and after lidocaine injection. We created demand ischemia in pigs before and after administering lidocaine(5 mg/kg) in eight open-pericardium anesthetized pigs. Demand ischemia was induced by constricting the left anterior descending coronary artery and then pacing at 1.5-1.8 times the baseline heart rate for 1.5-3 min. Hemodynamics were recorded during baseline, demand ischemia, baseline after lidocaine injection, and demand ischemia after Lidocaine. Lidocaine did not affect systolic function or the time constant of isovolumic relaxation, but it increased the upward shift of the diastolic pressure-volume curve during demand ischemia compared with the increase that occurred before Lidocaine was administered. This result suggests that lidocaine could aggravate diastolic dysfunction in patients with ischemic heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:19:14