Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXERCISE TRAINING ENHANCES BASIC FIBROBLAST GROWTH FACTOR-INDUCED COLLATERAL BLOOD-FLOW
Autore:
YANG HT; OGILVIE RW; TERJUNG RL;
Indirizzi:
UNIV MISSOURI,DEPT VET BIOMED SCI,SCH VET MED,E102 VET MED BLDG COLUMBIA MO 65211 SUNY HLTH SCI CTR,DEPT PHYSIOL SYRACUSE NY 13210 MED UNIV S CAROLINA,DEPT CELL BIOL & ANAT CHARLESTON SC 29425
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 43, anno: 1998,
pagine: 2053 - 2061
SICI:
0363-6135(1998)43:6<2053:ETEBFG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIAL INSUFFICIENCY; INTERMITTENT CLAUDICATION; THERAPEUTIC ANGIOGENESIS; MUSCLE ADAPTATIONS; WALKING TOLERANCE; SKELETAL-MUSCLE; RAT HINDLIMB; RABBIT MODEL; ENDOTHELIUM; INTENSITY;
Keywords:
VASCULAR REMODELING; ANGIOGENESIS; INTERMITTENT CLAUDICATION; MUSCLE CONTRACTION; MUSCLE FIBER TYPE; MICROSPHERES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
H.T. Yang et al., "EXERCISE TRAINING ENHANCES BASIC FIBROBLAST GROWTH FACTOR-INDUCED COLLATERAL BLOOD-FLOW", American journal of physiology. Heart and circulatory physiology, 43(6), 1998, pp. 2053-2061

Abstract

This study evaluated whether daily exercise would enhance the peripheral collateral vessel development found in response to exogenous basicfibroblast growth factor (bFGF) infusion. After bilateral femoral occlusion, male Sprague-Dawley rats (similar to 325 g) received intra-arterial infusions of either bFGF (1 mu g/day; n = 15) or carrier solution (n = 13) via osmotic pumps for 2 wk. Subgroups of each treatment were kept sedentary (cage activity) or trained by walking at 20 m/min at 15% grade, two times a day, 5 days/wk for 4 wk. Training markedly increased citrate synthase activity in the active muscle (P < 0.001). Muscle function and blood flows (Sr-85 microsphere) were evaluated using an isolated hindquarter perfused at 100 mmHg via the abdominal aorta. The significant increase in blood flow to the entire hindlimb in the sedentary animals, caused by bFGF infusion (P < 0.05), was further increased (P < 0.01) in the bFGF-trained group. The quantitatively largest increases in blood flows were observed in the collateral-dependent tissues of the distal hindlimb. Blood flows to the entire calf muscle group increased similar to 140% in carrier-trained (P < 0.001), similar to 180% in bFGF sedentary (P < 0.001), and similar to 240% in the bFGF-trained (P < 0.001) groups compared with the carrier sedentary group. The increases in collateral blood flow were functionally important, asimprovements in calf muscle performance correlated with measured blood flows. Our results demonstrate that exogenous bFGF administration incombination with a moderate-intensity exercise program greatly increases collateral-dependent blood flow and improves muscle performance. That physical activity enriched the bFGF response is consistent with the hypothesis that hemodynamic factors are important contributors to collateral vessel enlargement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:28:16