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Titolo:
PHYSIOLOGICAL DEGRADATION CONVERTS THE SOLUBLE SYNDECAN-1 ECTODOMAIN FROM AN INHIBITOR TO A POTENT ACTIVATOR OF FGF-2
Autore:
KATO M; WANG HM; KAINULAINEN V; FITZGERALD ML; LEDBETTER S; ORNITZ DM; BERNFIELD M;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT PEDIAT,300 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT PEDIAT BOSTON MA 02115 GENZYME CORP FRAMINGHAM MA 01710 WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Nature medicine
fascicolo: 6, volume: 4, anno: 1998,
pagine: 691 - 697
SICI:
1078-8956(1998)4:6<691:PDCTSS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCANS; MAMMARY EPITHELIAL-CELLS; EXTRACELLULAR-MATRIX; SURFACE PROTEOGLYCAN; ENDOTHELIAL-CELLS; RECEPTOR; BINDING; LOCALIZATION; MITOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Kato et al., "PHYSIOLOGICAL DEGRADATION CONVERTS THE SOLUBLE SYNDECAN-1 ECTODOMAIN FROM AN INHIBITOR TO A POTENT ACTIVATOR OF FGF-2", Nature medicine, 4(6), 1998, pp. 691-697

Abstract

The activity of fibroblast growth factor 2 (FGF-2) is stringently controlled. Inactive in undisturbed tissues, it is activated during injury and is critical for tissue repair. We find that this control can be imposed by the soluble syndecan-1 ectodomain, a heparan sulfate proteoglycan shed from cell surfaces into wound fluids. The ectodomain potently inhibits heparin-mediated FGF-2 mitogenicity because of the poorlysulfated domains in its heparin sulfate chains. Degradation of these regions by platelet heparanase produces heparin-like heparin sulfate fragments that markedly activate FCF-2 mitogenicity and are found in wound fluids. These results establish a novel physiological control for FGF-2 and suggest new ways to modulate FGF activity.

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Documento generato il 31/05/20 alle ore 19:41:21