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Titolo:
CORRELATION BETWEEN MYOCARDIAL BLOOD-FLOW AND FASTING GLUCOSE-METABOLISM IN ISCHEMIC-HEART-DISEASE - QUANTITATIVE ASSESSMENT BY N-13 AMMONIA AND F-18 FLUORODEOXYGLUCOSE POSITRON-EMISSION-TOMOGRAPHY
Autore:
WATANABE T; OKAZAKI O; AKUTSU Y; YAMANAKI H; MICHIHATA T; KATAGIRI T; HARUMI K;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTERNAL MED,6431 FANNIN,MSB 6-039 HOUSTON TX77030 SHOWA UNIV,SCH MED,DEPT INTERNAL MED 4 TOKYO 142 JAPAN
Titolo Testata:
Japanese Heart Journal
fascicolo: 3, volume: 39, anno: 1998,
pagine: 275 - 285
SICI:
0021-4868(1998)39:3<275:CBMBAF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-13 AMMONIA; WALL-MOTION; PERFUSION; QUANTIFICATION; FLUORINE-18-DEOXYGLUCOSE; INFARCTION; EXERCISE; TISSUE;
Keywords:
MYOCARDIAL BLOOD FLOW; GLUCOSE METABOLISM; ISCHEMIC HEART DISEASE; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Watanabe et al., "CORRELATION BETWEEN MYOCARDIAL BLOOD-FLOW AND FASTING GLUCOSE-METABOLISM IN ISCHEMIC-HEART-DISEASE - QUANTITATIVE ASSESSMENT BY N-13 AMMONIA AND F-18 FLUORODEOXYGLUCOSE POSITRON-EMISSION-TOMOGRAPHY", Japanese Heart Journal, 39(3), 1998, pp. 275-285

Abstract

Ischemic myocardium avidly incorporates fluorine-18 fluorodeoxyglucose (F-18 FDG) in the fasting state, in contrast to the relative absenceof F-18 FDG uptake in normal myocardium with sufficient blood flow inthe fasting state. Although many studies have attempted to use F-18 FDG uptake to discriminate ischemic but viable myocardium from scarred myocardium, little is known clinically about the correlation between blood flow and F-18 FDG uptake in ischemic myocardium. We studied the critical level of blood flow that causes avid F-18 FDG uptake in myocardium in 9 patients. All patients had angiographically proven ischemic heart disease but no diabetes. Regional myocardial blood flow (RMBF) was measured quantitatively by positron emission tomography (PET) usingnitrogen-13 ammonia in the resting state, in which the normal value was 80.2 +/- 13.0 ml/min/100 cm(3). The F-18 FDG uptake in myocardium was assessed with the differential uptake ratio (DUR) scale. We constructed circumferential profiles of radioactivity uptake in myocardium for each study, and chose 780 sections of myocardium in which the relation between the two factors could be analyzed. In moderately ischemic to normal myocardium with RMBF of 50 to 90 ml/min/100 cm(3), RMBF and F-18 FDG uptake were negatively correlated (r = -0.44, p < 0.01). When RMBF was 50 to 60 ml/min/100 cm(3) (n = 121), the peak DUR value of F-18 FDG uptake was 4.0 +/- 2.0. The two factors were not correlated when RMBF was less than 50 ml/min/100 cm(3) or 90 ml/min/100 cm(3) or higher. Our results suggest that RMBF and F-18 FDG uptake values as measured with PET may provide valuable information on the possible benefit of intervention in ischemic heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:43:32