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Titolo:
CLONING AND SEQUENCING OF AN ALTERNATIVE SPLICING-DERIVED CDNA VARIANT OF THE GM-CSF RECEPTOR-ALPHA SUBUNIT, WHICH ENCODES A TRUNCATED PROTEIN
Autore:
HU XT; ZUCKERMAN KS;
Indirizzi:
UNIV S FLORIDA,COLL MED,H LEE MOFFITT CANC CTR & RES INST,DEPT INTERNAL MED TAMPA FL 33612 UNIV S FLORIDA,COLL MED,H LEE MOFFITT CANC CTR & RES INST,DEPT INTERNAL MED TAMPA FL 33612 UNIV S FLORIDA,COLL MED,H LEE MOFFITT CANC CTR & RES INST,DEPT BIOCHEM & MOL BIOL TAMPA FL 33612
Titolo Testata:
American journal of hematology
fascicolo: 2, volume: 58, anno: 1998,
pagine: 145 - 147
SICI:
0361-8609(1998)58:2<145:CASOAA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; GRANULOCYTE; RNA;
Keywords:
GM-CSF RECEPTOR; ALTERNATIVE SPLICING; JUVENILE MYELOMONOCYTIC LEUKEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
X.T. Hu e K.S. Zuckerman, "CLONING AND SEQUENCING OF AN ALTERNATIVE SPLICING-DERIVED CDNA VARIANT OF THE GM-CSF RECEPTOR-ALPHA SUBUNIT, WHICH ENCODES A TRUNCATED PROTEIN", American journal of hematology, 58(2), 1998, pp. 145-147

Abstract

GM-CSF interacts with the low affinity GM-CSF receptor alpha-subunit,which leads to high affinity association with the alpha-subunit/common beta-subunit complex and transduction of intracellular signals leading to proliferation, differentiation, and/or activation of hemopoieticcells, predominantly in the neutrophil and monocyte/macrophage lineages. Several alternative splicing-derived variants of the GM-CSF receptor alpha-subunit have been described previously by this and other laboratories. A newly discovered alternative-splicing derived variant was isolated from the peripheral blood mononuclear cells of a patient withjuvenile myelomonocytic leukemia. This variant lacks 397 base pairs corresponding to exons 8-11 of the wild type GM-CSF receptor alpha-subunit cDNA and potentially encodes a 233 amino acid protein lacking a membrane-anchoring domain and creating the fourth known potential soluble isoform of the alpha-subunit of the GM-CSF receptor. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:00:20