Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SUPPRESSION OF PROSTANOID FORMATION AND REGULATION OF PERIPHERAL-CIRCULATION AFTER SURGERY USING THROMBIN INHIBITOR (MD805)
Autore:
ONIZUKA M; ISHIKAWA S; ISHIBASHI O; SUGA M; MITSUI K; MITSUI T;
Indirizzi:
UNIV TSUKUBA,INST CLIN MED,DEPT SURG IBARAKI OSAKA 305 JAPAN
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 6, volume: 28, anno: 1998,
pagine: 618 - 625
SICI:
0941-1291(1998)28:6<618:SOPFAR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTITHROMBIN-III COMPLEX; HUMAN ENDOTHELIAL-CELLS; ARACHIDONIC-ACID; PROSTAGLANDINS MEDIATE; VASOACTIVE SUBSTANCES; PLASMA; PROSTACYCLIN; THROMBOXANE; GENERATION; MECHANISM;
Keywords:
ENDOGENOUS THROMBIN; PROSTANOIDS; PERIPHERAL CIRCULATION; SURGICAL STRESS; HEMODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
M. Onizuka et al., "SUPPRESSION OF PROSTANOID FORMATION AND REGULATION OF PERIPHERAL-CIRCULATION AFTER SURGERY USING THROMBIN INHIBITOR (MD805)", SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 28(6), 1998, pp. 618-625

Abstract

We studied the effects of thrombin generation due to surgical stress on prostanoid formation and peripheral circulation in anesthetized dogs. Three experimental groups were used, consisting of a control group (group 1), a thoracotomized group (group 2), and a thoracotomized group treated with thrombin inhibitor (MD805: a synthetic arginine derivative) (group 3), The plasma concentrations of thrombin-antithrombin IIIcomplex (TAT) and prostanoids were measured along with the hemodynamic parameters. The plasma concentrations of TAT and thromboxane B-2 sigmificantly increased 1 h after a thoracotomy in group 2. However, neither concentration increased after a thoracotomy in group 3. The flow ratio of the brachial and femoral arteries to cardiac output significantly decreased 1 h after a thoracotomy in group 2, The's study indicates that thromboxane A(2) was thus synthesized by the stimulation of endogenous thrombin, while it also reduced the peripheral blood flow after surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:48:05