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Titolo:
HEMORHEOLOGICAL ABNORMALITIES IN RATS WITH EXPERIMENTAL MILD DIABETES- IMPROVING EFFECT OF TROXERUTINE AND ALPHA-TOCOPHEROL
Autore:
BERTHAULT MF; OTHMANE A; GUILLOU J; COUNORD JL; KTORZA A; DUFAUX J;
Indirizzi:
UNIV PARIS 07,PHYSIOPATHOL NUTR LAB,CNRS,URA 307,2 PL JUSSIEU F-75251PARIS 05 FRANCE UNIV PARIS 07,PHYSIOPATHOL NUTR LAB,CNRS,URA 307,2 PL JUSSIEU F-75251PARIS 05 FRANCE UNIV PARIS 07,BIORHEOL & HYDRODYNAM PHYSICOCHIM LAB,CNRS,URA 343 F-75251 PARIS 05 FRANCE RHONE POULENC RORER THERAPLIX F-75640 PARIS 13 FRANCE
Titolo Testata:
Clinical hemorheology
fascicolo: 1, volume: 14, anno: 1994,
pagine: 83 - 92
SICI:
0271-5198(1994)14:1<83:HAIRWE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN; VELOCITY; FLOW;
Keywords:
BLOOD FLOW; RED BLOOD CELL AGGREGATION; WHITE BLOOD CELL ADHESIVITY; TROXERUTINE; DIABETES; VITAMIN-E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Berthault et al., "HEMORHEOLOGICAL ABNORMALITIES IN RATS WITH EXPERIMENTAL MILD DIABETES- IMPROVING EFFECT OF TROXERUTINE AND ALPHA-TOCOPHEROL", Clinical hemorheology, 14(1), 1994, pp. 83-92

Abstract

We investigated the effect of intravenous 2mM Troxerutine and 10mM alpha-Tocopherol (Vitamin E) and their combination on erythrocyte aggregation and deformability, blood viscosity and leukocyte adhesivity in rats made mildly diabetic (fasting glycemia: 10mM vs 6mM in controls; HbA1c: 6.5% vs 3% in controls) by a low dose of streptozotocin (35mg/kg) injected via the saphenous vein. In diabetic rats, as compared to controls, erythrocyte aggregation and blood viscosity were dramatically increased (disaggregation shear stress: 5.2 +/- 0.4 dynes/cm2 vs 3.7 +/- 0.3 dynes/cm2 in controls), whereas erythrocyte deformability and mesenteric blood flow were sharply decreased. Moreover, leukocyte adhesivity was significantly increased. In diabetic rats, the combination of Troxerutine and Tocopherol improved all the above cited parameters. These data show that mild diabetes in rats results in many hemorheological disorders that can be largely corrected by Troxerutine and alpha-Tocopherol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 04:45:21