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Titolo:
Antiviral activities of biflavonoids
Autore:
Lin, YM; Flavin, MT; Schure, R; Chen, FC; Sidwell, R; Barnard, DL; Huffman, JH; Kern, ER;
Indirizzi:
Medichem Res Inc, Lemont, IL 60439 USA Medichem Res Inc Lemont IL USA 60439 dichem Res Inc, Lemont, IL 60439 USA Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 iv, Dept Chem, Taipei 10764, Taiwan Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA Utah State Univ Logan UT USA 84322 nst Antiviral Res, Logan, UT 84322 USA Univ Alabama, Dept Pediat, Birmingham, AL USA Univ Alabama Birmingham AL USA Alabama, Dept Pediat, Birmingham, AL USA
Titolo Testata:
PLANTA MEDICA
fascicolo: 2, volume: 65, anno: 1999,
pagine: 120 - 125
SICI:
0032-0943(199903)65:2<120:AAOB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GARCINIA-MULTIFLORA; RHUS-SUCCEDANEA; IN-VITRO; ROBUSTAFLAVONE; AGENT;
Keywords:
biflavonoid; antiviral activities; respiratory viruses; herpes viruses; influenza A virus; influenza B virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, YM Medichem Res Inc, 12305 S New ave, Lemont, IL 60439 USA Medichem Res Inc 12305 S New ave Lemont IL USA 60439 IL 60439 USA
Citazione:
Y.M. Lin et al., "Antiviral activities of biflavonoids", PLANTA MED, 65(2), 1999, pp. 120-125

Abstract

Biflavonoids such as amentoflavone (1), agathisflavone (2), robustaflavone(3), hinokifiavone (4), volkensiflavone (5), rhusflavanone (7), succedaneaflavanone (9), all isolated from Rhus succedonea and Garcinia multiflora, as well as their methyl ethers and acetates, volkensiflavone hexamethyl ether (6), rhusflavanone hexaacetate (8), and succedaneaflavanone hexaacetate (10) were evaluated for their antiviral activities. The inhibitory activities against a number of viruses including respiratory viruses (influenza A, influenza B, respiratory syncytial, parainfluenza type 3, adenovirus type 5,and measles) and herpes viruses (HSV-1, HSV-2, HCMV, and VZV) were investigated. The results indicated that robustaflavone exhibited strong inhibitory effects against influenza A and influenza 8 viruses with EC50 values of 2.0 mu g/ml and 0.2 mu g/ml, respectively, and selectivity index values (SI)of 16 and 454, respectively. Amentoflavone and agathisflavone also demonstrated significant activity against influenza A and B viruses. Amentoflavoneand robustaflavone exhibited moderate anti-HSV-1 and anti-HSV-2 activitieswith EC50 values of 17.9 mu g/ml (HSV-1) and 48.0 mu g/ml (HSV-2) and SI values of >5.6 (HSV-1) and >2.1 (HSV-2) for amentoflavone; EC50 values of 8.6 mu g/ml (HSV-1) and 8.5 mu g/ml (HSV-2), and SI values of >11.6 (HSV-1) and >11.8 (HSV-2) for robustaflavone. Rhusflavanone demonstrated inhibitory activities against influenza B, measles, and HSV-2 viruses with SI values of 9.3, 8 and >6.4, respectively. Succedaneaflavanone exhibited inhibitory activities against influenza B virus and VZV with SI values of 15 and <3.0, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:57:22