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Titolo:
CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease
Autore:
Atkinson, A; Singleton, AB; Steward, A; Ince, PG; Perry, RH; McKeith, IG; Fairbairn, AF; Edwardson, JA; Daly, AK; Morris, CM;
Indirizzi:
Newcastle,Gen Hosp, MRC, Neurochem Pathol Unit, Newcastle Upon Tyne NE4 6BE Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE E4 6BE NewcastleWear,Hosp, Inst Hlth Elderly, Newcastle Upon Tyne NE4 6BE, Tyne &Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE Tyne & Newcastleear, Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & W Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ne & W NewcastleeGen Hosp, Dept Old Age Psychiat, Newcastle Upon Tyne NE4 6BE, Tyn Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE E, Tyn UnivTynecastle Upon Tyne, Dept Pharmacol Sci, Newcastle Upon Tyne NE1 7RU,Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE1 7RU Univ Sunderland, Sch Hlth Sci, Sunderland SR2 7EE, England Univ Sunderland Sunderland England SR2 7EE , Sunderland SR2 7EE, England
Titolo Testata:
PHARMACOGENETICS
fascicolo: 1, volume: 9, anno: 1999,
pagine: 31 - 35
SICI:
0960-314X(199902)9:1<31:CIAWPD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE GENE POLYMORPHISM; APOLIPOPROTEIN-E GENOTYPE; E ALLELE EPSILON-4; OXIDASE-B GENE; MONOAMINE-OXIDASE; BODY DISEASE; SENILE DEMENTIA; NO ASSOCIATION; FREQUENCIES; ONSET;
Keywords:
Alzheimer's disease; dementia with Lewy bodies; Parkinson's disease; CYP2D6; apolipoprotein E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, CM Newcastle,Gen Hosp, MRC, Neurochem Pathol Unit, Newcastle Upon Tyne NE4 6BE Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE
Citazione:
A. Atkinson et al., "CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease", PHARMACOGEN, 9(1), 1999, pp. 31-35

Abstract

The similarities between the clinical and pathological findings of dementia with Lewy Bodies (DLB) with Alzheimer's disease and Parkinson's disease are complex, and their significance for pathogenesis is unresolved It is likely that DLB shares common disease determinants with both Alzheimer's disease and Parkinson's disease. Clinically DLB shows the presence of dementia similar, though not identical, to that found in Alzheimer's disease. A parkinsonian movement disorder is present in a proportion of DLB cases, Pathologically DLB shows senile plaques, as with Alzheimer's disease, and also substantia nigra neurone loss and Lewy bodies, as with Parkinson's disease, At a genetic level, DLB shows an elevated Apolipoprotein E epsilon 4 frequencyas described in Alzheimer's disease, but this is absent in Parkinson's disease. An elevated frequency of the CYP2D6*4 allele has been found in Parkinson's disease and we have therefore genotyped a large series of clinically and neuropathologically confirmed cases of DLB, Alzheimer's disease, Parkinson's disease and age-matched control individuals for the CYP2D6*4 allele, Whilst an elevated frequency of the CYP2D6*4 allele was found in Parkinson's disease, no such elevations were found in DLB or Alzheimer's disease, Stratification of the CYP2D6*4 allele with respect to the Apolipoprotein E epsilon 4 also did not show any significant associations with the CYP2D6*4 allele, The CYP2D6*4 allele is not a major genetic determinant of DLB and the results place DLB with Alzheimer's disease rather than Parkinson's disease on a genetic level, Pharmacogenetics 9:31-35 (C) 1999 Lippincott Williams &Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:32:46