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Titolo:
Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat?
Autore:
Catheline, G; Le Guen, S; Honore, P; Besson, JM;
Indirizzi:
INSERM U161, Unite Rech Physiopharmacol Syst Nerveux, F-75014 Paris, France INSERM U161 Paris France F-75014 col Syst Nerveux, F-75014 Paris, France EPHE, F-75014 Paris, France EPHE Paris France F-75014EPHE, F-75014 Paris, France
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 80, anno: 1999,
pagine: 347 - 357
SICI:
0304-3959(199903)80:1-2<347:ATLCIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PERIPHERAL NEUROPATHY; PAIN-RELATED BEHAVIORS; CHRONIC CONSTRICTION INJURY; CHRONIC NERVE CONSTRICTION; SCIATIC-NERVE; TIME-COURSE; SPONTANEOUS DISCHARGE; CHRONIC ARTHRITIS; ROOT POTENTIALS; FIBER LOSS;
Keywords:
Fos protein; spinal cord; neuropathic pain; chronic constriction injury; hyperalgesia; allodynia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Catheline, G INSERM4U161, Unite Rech Physiopharmacol Syst Nerveux, 2 Rue dAlesia, F-7501 INSERM U161 2 Rue dAlesia Paris France F-75014 lesia, F-7501
Citazione:
G. Catheline et al., "Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat?", PAIN, 80(1-2), 1999, pp. 347-357

Abstract

The long-term changes in Fos like-immunoreactivity (Fos-LI) in the dorsal horn of the spinal cord following various peripheral nerve lesions remain controversial. This study considers such an approach with chronic constriction injury rats (CCI: loose ligations of the sciatic nerve), at 2 weeks after the surgery, when changes in spontaneous and evoked behaviour were clearly described. All rats used for Fos studies displayed allodynia to mechanical stimulation (decrease of 32% of the vocalization threshold to paw pressure). In CCI rats, which displayed 'spontaneous pain-related behaviour', the number of Fos-LI neurones, in the absence of any intentional stimulation, was very low and comparable with that observed in normal and sham-operated rats (<10 neurones/40 mu m section). Thus, in this model, the expression of Fos protein is not a reliable index of spontaneous pain. Surprisingly, despite the fact that in this model numerous anatomical studies described a dramatic loss of large and unmyelinated primary afferent fibers, we were unable to detect changes in the number and distribution of Fos-LI evoked by various modalities of peripheral noxious stimulation (noxious thermal stimuli, noxious mechanical stimuli and carrageenin induced inflammation). For example, the stimulus-response curves for the number of Fos-LI neurones evoked by a series of heat stimuli (40, 45, 48, 52, 55 degrees C) were almost superimposable for CCI, sham-operated and normal rats. In contrast, seeking of the nerve-injured paw induced a significant expression of Fos-LI in the superficial laminae (I-II) of the dorsal horn of CCI rats (19.5 +/- 3/sections,P = 0.027) which was greater than that observed in sham-operated (6.5 +/- 3/sections) or in normal rats (3.5 +/- 2/section). These modifications may reflect mechanical allodynia observed in behavioural studies and could be related to AP fibers, which are known to be severely affected after the constriction of the nerve. These results suggest that this approach could be useful to study, at the cellular level, in freely moving rats, some pharmacological aspects of neuropathic pain. (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:54:31