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Titolo:
Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: Involvement in frontostriatal cognitive deficits
Autore:
Jentsch, JD; Taylor, JR; Elsworth, JD; Redmond, DE; Roth, RH;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Neurosurg, New Haven, CT 06510 USA Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Neurobiol Sect, New Haven, CT 06520 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 90, anno: 1999,
pagine: 823 - 832
SICI:
0306-4522(1999)90:3<823:AFCDTI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOLATERAL PREFRONTAL CORTEX; CEREBRAL BLOOD-FLOW; CARD SORT TEST; OBJECT RETRIEVAL; RHESUS-MONKEY; 6-HYDROXYDOPAMINE LESIONS; ELECTRICAL-STIMULATION; INDUCED PSYCHOSIS; WORKING-MEMORY; MOTOR DEFICITS;
Keywords:
dopamine; phencyclidine; prefrontal cortex; psychotomimetic; serotonin; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Roth, RH Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 l Sect, New Haven, CT 06520 USA
Citazione:
J.D. Jentsch et al., "Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: Involvement in frontostriatal cognitive deficits", NEUROSCIENC, 90(3), 1999, pp. 823-832

Abstract

Long-term exposure to the psychotomimetic drug phencyclidine produces prefrontal cortical cognitive and dopaminergic dysfunction in rats and monkeys,effects possibly relevant to the frontal cortical impairments of schizophrenia. In the present study, the effects of subchronic phencyclidine administration (0.3 mg/kg twice-daily for 14 days) on monoamine systems in the monkey brain were examined and related to cognitive performance on an object retrieval/detour task, which has been linked with frontostriatal function. Long-term (14 days) administration of phencyclidine resulted in a marked andpersistent reduction in dopamine utilization in the frontal cortex. Moreover, the degree of cognitive impairment in phencyclidine-treated monkeys correlated significantly with the magnitude of dopaminergic inhibition within the dorsolateral prefrontal cortex and prelimbic cortex. No specific correlation was measured for dopamine utilization in other cortical regions or for indices of serotonin transmission in any brain region. These data show that repeated exposure to phencyclidine reduces prefrontalcortical dopamine transmission, and this inhibition of dopaminergic function is associated with performance impairments on a task sensitive to frontostriatal cognitive dysfunction. Thus, the cognitive deficits of phencyclidine-treated monkeys, as in schizophrenia, appear to be mediated, in part, byreduced dopaminergic function in specific subregions of the frontal cortex. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 01/04/20 alle ore 21:58:19