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Titolo:
Age-related attenuation of stimulated cortical acetylcholine release in basal forebrain-lesioned rats
Autore:
Fadel, J; Sarter, M; Bruno, JP;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Neurosci Program, Columbus, OH 43210 USA Ohio State UnivColumbus OH USA 43210 sci Program, Columbus, OH 43210 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 90, anno: 1999,
pagine: 793 - 802
SICI:
0306-4522(1999)90:3<793:AAOSCA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR LIGANDS; ALZHEIMERS-DISEASE; BIDIRECTIONAL MODULATION; COGNITIVE FUNCTIONS; CHOLINERGIC SYSTEM; NUCLEUS BASALIS; EFFLUX; PERFORMANCE; SELECTIVITY; NEURONS;
Keywords:
ageing; cortex; acetylcholine; microdialysis; 192 immunoglobulin G saporin; basal forebrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bruno, JP Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio StateUniv Columbus OH USA 43210 l, Columbus, OH 43210 USA
Citazione:
J. Fadel et al., "Age-related attenuation of stimulated cortical acetylcholine release in basal forebrain-lesioned rats", NEUROSCIENC, 90(3), 1999, pp. 793-802

Abstract

In vivo microdialysis was used to measure the effects of partial deafferentation of cortical cholinergic inputs on acetylcholine efflux in young (four to seven months) and aged (24-28 months) male F344/BNNIA rats. Partial deafferentation was produced by bilateral infusions of the immunotoxin 192 immunoglobulin G-saporin (0.56 mu g/1.0 mu l) or its vehicle solution into the ventral pallidum/substantia innominata region of the basal forebrain. Thelesion produced comparable (65%) decreases in basal cortical acetylcholineefflux in young and aged rats. Presentation of a complex environmental stimulus (exposure to darkness/palatable food), in conjunction with the systemic administration of the benzodiazepine receptor weak inverse agonist ZK 93426, increased cortical acetylcholine efflux in young shams, aged shams and young lesioned rats, but not in aged lesioned rats. Administration of thebenzodiazepine receptor partial inverse agonist FG 7142, in the absence ofthe environmental stimulus, comparably stimulated cortical acetylcholine efflux in young and aged sham rats. FG 7142-induced increases in acetylcholine efflux were attenuated by approximately 50% following partial deafferentation in both young and aged rats. These results suggests that, under certain conditions, ageing potently interacts with the integrity of the cortical cholinergic afferent system. The effects of ageing on cortical cholinergic function may be most potently revealed by experiments assessing age-related limitations in the responsiveness of a partially deafferented cholinergic system to certain behavioral and/or pharmacological stimuli. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 19/01/20 alle ore 09:29:26