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Titolo:
Cultured motor neurons possess calcium-permeable AMPA/kainate receptors
Autore:
Bar-Peled, O; OBrien, RJ; Morrison, JH; Rothstein, JD;
Indirizzi:
Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 Neurol, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Neurosci, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 urosci, Baltimore, MD 21287 USA Mt Sinai Sch Med, Dept Neurobiol, New York, NY USA Mt Sinai Sch Med New York NY USA h Med, Dept Neurobiol, New York, NY USA
Titolo Testata:
NEUROREPORT
fascicolo: 4, volume: 10, anno: 1999,
pagine: 855 - 859
SICI:
0959-4965(19990317)10:4<855:CMNPCA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; AMYOTROPHIC-LATERAL-SCLEROSIS; CA2+ PERMEABILITY; GLUTAMATE RECEPTORS; IN-VITRO; SUBUNIT; EXPRESSION; CHANNELS; INJURY; MODEL;
Keywords:
ALS; Ca2+-permeable AMPA/kainate receptors; GluR2; motor neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rothstein, JD Johns21287ins Univ, Dept Neurol, 600 N Wolfe St,Meyer 6-109,Baltimore, MD Johns Hopkins Univ 600 N Wolfe St,Meyer 6-109 Baltimore MD USA 21287
Citazione:
O. Bar-Peled et al., "Cultured motor neurons possess calcium-permeable AMPA/kainate receptors", NEUROREPORT, 10(4), 1999, pp. 855-859

Abstract

WE examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodieswhich enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate exposure, labeled motor neurons in spinal cord cultures. The analysis of AMPA subunit distribution in dissociated motor neurons revealed a unique pattern of glutamate receptor (GluR) subunits in those cells;the GluR1 subunit was found in all spinal cord neurons, but the GluR2 subunit was not found in identified dissociated motor neurons. These data suggest that selective sensitivity of motor neurons to non-NMDA receptor activation is due, at least in part, to the presence of Ca2+-permeable AMPA/kainate receptors. NeuroReport 10:855-859 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:52:10