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Titolo:
Opposing effects of two CCKB agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat
Autore:
Lena, I; Simon, H; Roques, BP; Dauge, V;
Indirizzi:
UFR Sci Pharmaceut & Biol, INSERM U266, Dept Pharmacochim Mol & Struct, URA UFR Sci Pharmaceut & Biol Paris France 06 Pharmacochim Mol & Struct, URA Univ076rdeaux 2, INSERM U259, Lab Psychobiol Comportements Adaptatifs, F-33 Univ Bordeaux 2 Bordeaux France F-33076 l Comportements Adaptatifs, F-33
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 4, volume: 38, anno: 1999,
pagine: 543 - 553
SICI:
0028-3908(199904)38:4<543:OEOTCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
B RECEPTOR; CHOLECYSTOKININ ANTAGONIST; MORPHINE ANALGESIA; NUCLEUS-ACCUMBENS; BRAIN; CELLS; AMPHETAMINE; L-365,260; AFFINITY; DOPAMINE;
Keywords:
spatial recognition memory; retrieval processes; CCKB agonists; BC 197 and BC 264; CCKB receptors heterogeneity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Dauge, V UFR Sci Pharmaceut & Biol, INSERM U266, Dept Pharmacochim Mol & Struct, URA UFR Sci Pharmaceut & Biol 4 Ave Observ Paris France 06 ruct, URA
Citazione:
I. Lena et al., "Opposing effects of two CCKB agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat", NEUROPHARM, 38(4), 1999, pp. 543-553

Abstract

The effects of two selective CCKB agonists, BC 264 and BC 197, on memory processes were investigated in rats using a recently developed two-trial recognition memory task. Control animals showed recognition memory after a 2 but not a 6 h time interval between the two trials, thus allowing a memory impairing (2 h) or improving (6 h) effect of pharmacological treatments to be measured. Drugs were injected i.p. before the second trial (retrieval phase). This experimental procedure was first studied with scopolamine and DL-amphetamine, for which a significant deficit after a 2 h interval or improvement after a 6 h interval of performance was observed, respectively. The CCKB agonist, BC 264, was ineffective after a 2 h time interval, whereas thedose of 0.3 mu g/kg significantly enhanced performance after a 6 h inter-trial interval. In contrast, BC 197 (30 mu g/kg) produced a significant disruption of performance after a 2 h inter-trial interval but was without effect after a 6 h time interval. The effects of the two CCKB agonists were abolished by pretreatment with a selective CCKB antagonist, L365,260 but not by a selective CCKA antagonist, L364,718. The present results suggest that CCKB receptors display functional heterogeneity and that CCKB agonists like BC 264 could offer a new perspective for the treatment of attentional and/or memory deficits. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:10:00