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Titolo:
Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat
Autore:
Becker, C; Hamon, M; Benoliel, JJ;
Indirizzi:
Fac Med Pitie Salpetriere, INSERM, U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere Paris France 13 U288, F-75634 Paris 13, France Fac Med Pitie Salpetriere, Serv Biochim Med, F-75634 Paris, France Fac MedPitie Salpetriere Paris France F-75634 ed, F-75634 Paris, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 4, volume: 38, anno: 1999,
pagine: 525 - 532
SICI:
0028-3908(199904)38:4<525:PB5RAO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS RAPHE DORSALIS; INDUCED PANIC ATTACKS; ANIMAL-MODELS; SPINAL-CORD; PLUS-MAZE; ANTAGONIST; IMMUNOREACTIVITY; INVOLVEMENT; BEHAVIOR; ANXIETY;
Keywords:
cholecystokinin; in vivo microdialysis; frontal cortex; 5-H-1A receptor agonists; restraint stress; yohimbine-induced anxiety related behaviour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Becker, C Facnced Pitie Salpetriere, INSERM, U288, 91 Blvd Hop, F-75634 Paris 13, Fra Fac Med Pitie Salpetriere 91 Blvd Hop Paris France 13 s 13, Fra
Citazione:
C. Becker et al., "Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat", NEUROPHARM, 38(4), 1999, pp. 525-532

Abstract

In line with the idea that cholecystokinin (CCK) is involved in anxiety-related behaviours, previous investigations showed that stressful conditions and an 'anxiogenic' drug, yohimbine, increased the cortical release of CCK like-material (CCKLM) in awake rats, and that this effect could be prevented by diazepam. Here, we investigated whether other anxiolytic drugs such as5-HT1A receptor agonists could also affect cortical CCKLM release. Indeed,neither buspirone (1 mg/kg i.p.), alnespirone (1 mg/kg i.p.) nor lesopitron (3 mg/kg i.p.) affected, on their own, CCKLM release. However, pretreatment with the latter drugs completely abolished the stimulatory effect of restraint stress on the peptide outflow. As expected of the involvement of 5-HT1A receptors, tertatolol (10 mg/kg i.p) markedly reduced the inhibitory effect of buspirone on restraint stress-evoked CCKLM overflow. On the other hand, pretreatment with buspirone, alnespirone or lesopitron also inhibited the stimulatory effect of yohimbine (5 mg/kg i.p.) on cortical CCKLM outflow. These data support the idea that the anxiolytic action of 5-HT1A receptor agonists could be mediated, at least partly, through their inhibitory influence on cortical CCK-ergic systems. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:50:08