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Titolo:
Simultaneous effects of local dexfenfluramine application on extracellularglutamate and serotonin levels in rat frontal cortex: a reverse microdialysis study
Autore:
Rocher, C; Jacquot, C; Gardier, AM;
Indirizzi:
UnivADaris Sud, Fac Pharm, Inst Signalisat & Innovat Therapeut, IFR,UPRES E Univ Paris Sud Chatenay Malabry France F-92296 at Therapeut, IFR,UPRES E Univ Picardie, Fac Pharm, Pharmacol Lab, F-80037 Amiens, France Univ Picardie Amiens France F-80037 harmacol Lab, F-80037 Amiens, France
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 4, volume: 38, anno: 1999,
pagine: 513 - 523
SICI:
0028-3908(199904)38:4<513:SEOLDA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; IN-VIVO MICRODIALYSIS; D-FENFLURAMINE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; P-CHLOROAMPHETAMINE; D-NORFENFLURAMINE; INVIVO DIALYSIS; UPTAKE SITES; RELEASE; FLUOXETINE;
Keywords:
dexfenfluramine; frontocortical; glutamate; reverse microdialysis; serotonin; high performance liquid chromatography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Gardier, AM UnivADarisrance Fac Pharm, Inst Signalisat & Innovat Therapeut, IFR,UPRES E Univ Paris Sud Tour D1,2eme Etage Chatenay Malabry France F-92296
Citazione:
C. Rocher et al., "Simultaneous effects of local dexfenfluramine application on extracellularglutamate and serotonin levels in rat frontal cortex: a reverse microdialysis study", NEUROPHARM, 38(4), 1999, pp. 513-523

Abstract

We examined the effects of local perfusion by reverse dialysis of various doses of dexfenfluramine (D-fen; in mM: 2.4, 12, and 24) simultaneously on serotonin (5-HT; [5-HT](ext)) and glutamate (Glu; [Glu](ext)) extracellularlevels in the frontal cortex of awake rats. D-fen induced a dose-dependentincrease in both [5-HT](ext) and [Glu](ext), the latter being Ca2+ -dependent and TTX-sensitive, while the former is not. Pretreatment with either the neurotoxin p-chloroamphetamine or the 5-HT uptake blocker fluoxetine, markedly reduced the effects of D-fen on [5-HT](ext) and [Glu](ext) compared to controls. This indicates that intact 5-HT nerve terminals may be requiredfor D-fen to enter into neurones to release 5-HT by reversal of the 5-HT transporter, which then increases frontocortical [Glu](ext). Pretreatment with the Glu uptake blocker, L-trans-pyrrolidine-2,4-dicarboxylic acid (1 mM), significantly reduced by 40% the effect of D-fen's on [Glu](ext) suggesting that Glu uptake sites are partially involved in this effect. These results strongly suggest that intracortical application, by reverse dialysis, ofa high dose of D-fen increases frontocortical [Glu](ext) by a dual mechanism of action: (1) by stimulating 5-HT release (a major indirect effect) that, in turn, facilitates the release of neuronal Glu; (2) by reversal of theglutamate transporter (a minor direct effect being Ca2+ -independent and TTX-insensitive). (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:55:14