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Titolo:
No change in the density of the serotonin(1A) receptor, the serotonin(4) receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia
Autore:
Dean, B; Tomaskovic-Crook, E; Opeskin, K; Keks, N; Copolov, D;
Indirizzi:
Mentalkville,es Inst, Rebecca L Cooper Res Labs, Div Mol Schizophrenia, Par Mental Hlth Res Inst Parkville Vic Australia Div Mol Schizophrenia, Par Victorian Inst Forens Med, S Bank, Vic, Australia Victorian Inst Forens Med S Bank Vic Australia d, S Bank, Vic, Australia
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 2, volume: 34, anno: 1999,
pagine: 109 - 115
SICI:
0197-0186(199902)34:2<109:NCITDO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-CORTEX; AUTORADIOGRAPHIC ANALYSIS; DOPAMINE RELEASE; 5-HT1A RECEPTORS; BINDING SITES; RAT-BRAIN; INCREASE; POSTMORTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Dean, B Mentalkville,es Inst, Rebecca L Cooper Res Labs, Div Mol Schizophrenia, Par Mental Hlth Res Inst Parkville Vic Australia Schizophrenia, Par
Citazione:
B. Dean et al., "No change in the density of the serotonin(1A) receptor, the serotonin(4) receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia", NEUROCHEM I, 34(2), 1999, pp. 109-115

Abstract

Changes in serotonin receptors and the serotonin transporter have been reported in the dorsolateral prefrontal cortex from subjects with schizophrenia, an area of the brain thought to be important in the pathology of the illness. To further our understanding on how such changes could play a role inthe pathology of the illness, in situ radioligand binding with autoradiography was used to measure the density of the serotonin,, receptor, the serotonin, receptor and the serotonin transporter in the dorsolateral prefrontalcortex, obtained at autopsy, from 10 schizophrenic and 10 control subjects. The binding of [H-3]8-OH-DPAT to serotonin,, receptor, [H-3]GR113808 to the 5HT(4) receptor and [H-3]citalopram to serotonin transporter was not altered in subjects with schizophrenia. Significantly, only in tissue from thecontrol subjects was there a relationship between age and the density of the serotonin, receptor in Brodmann's areas 8 (r = 0.71, P = 0.02) and 10 (r= -0.67, P = 0.03). Importantly, this confounding factor did not influencethe comparison of the density of serotonin, receptor in the tissue from the schizophrenic and control subjects. This study has failed to show a difference in the density of serotonin(1A)receptor, the serotonin, receptor or the serotonin transporter in the dorsolateral prefrontal cortex (Brodmann's areas 8, 9 and 10) from subjects with schizophrenia. These data suggest that not all serotonergic markers are altered in the dorsolateral prefrontal cortex from schizophrenic subjects. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:29:21