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Titolo:
Blood flow and vascular gene expression: fluid shear stress as a modulatorof endothelial phenotype
Autore:
Topper, JN; Gimbrone, MA;
Indirizzi:
Stanfordtanford,ch Med, Falk Cardiovasc Res Ctr, Dept Med,Cardiovasc Div, S Stanford Univ Stanford CA USA 94305 c Res Ctr, Dept Med,Cardiovasc Div, S Brigham & Womens Hosp, Div Vasc Res, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 Vasc Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR MEDICINE TODAY
fascicolo: 1, volume: 5, anno: 1999,
pagine: 40 - 46
SICI:
1357-4310(199901)5:1<40:BFAVGE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SUPEROXIDE-DISMUTASE; MOLECULAR-CLONING; CHAIN PROMOTER; CELLS; ATHEROSCLEROSIS; ELEMENT; PULSATILE; ADHESION; STIMULI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Topper, JN Stanford00niv, Sch Med, Falk Cardiovasc Res Ctr, Dept Med,Cardiovasc Div, 3 Stanford Univ 300 Pasteur Dr Stanford CA USA 94305 ovasc Div, 3
Citazione:
J.N. Topper e M.A. Gimbrone, "Blood flow and vascular gene expression: fluid shear stress as a modulatorof endothelial phenotype", MOL MED TOD, 5(1), 1999, pp. 40-46

Abstract

Vascular endothelium, the cellular monolayer lining the entire cardiovascular system, is exposed to a variety of biochemical and biomechanical stimuli. Fluid shear stresses generated by blood flow in the vasculature can profoundly influence the phenotype of the endothelium by regulating the activity of certain flow-sensitive proteins (for example, enzymes), as well as by modulating gene expression. The finding that specific fluid mechanical forces can alter endothelial structure and function has provided a framework for a mechanistic understanding of flow-dependent processes, ranging from vascular remodeling in response to hemodynamic changes, to the initiation and localization of chronic vascular diseases such as atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 09:51:15