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Titolo:
Dopamine D-1 regulation of caudate neurotensin mRNA in the presence or absence of the nigrostriatal dopamine pathway
Autore:
Hanson, GR; Keefe, KA;
Indirizzi:
Univ Utah, Dept Pharmacol & Toxicol, Salt Lake City, UT 84112 USA Univ Utah Salt Lake City UT USA 84112 xicol, Salt Lake City, UT 84112 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 66, anno: 1999,
pagine: 111 - 121
SICI:
0169-328X(19990320)66:1-2<111:DDROCN>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; RAT-BRAIN; NUCLEUS-ACCUMBENS; GENE-EXPRESSION; C-FOS; ACUTE METHAMPHETAMINE; VENTRAL STRIATUM; NEURONS; HALOPERIDOL; NEOSTRIATUM;
Keywords:
neurotensin; dopamine; striatum; extrapyramidal; caudate nucleus; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hanson, GR Univ112ah, Dept Pharmacol & Toxicol, 112 Skaggs Hall, Salt LakeCity, UT 84 Univ Utah 112 Skaggs Hall Salt Lake City UT USA 84112 ty, UT 84
Citazione:
G.R. Hanson e K.A. Keefe, "Dopamine D-1 regulation of caudate neurotensin mRNA in the presence or absence of the nigrostriatal dopamine pathway", MOL BRAIN R, 66(1-2), 1999, pp. 111-121

Abstract

Changes in extrapyramidal dopamine (DA) function significantly alter the activity of striatal neurotensin (NT) systems. Specifically, stimulation of DA D-l or D-2 receptors increases or decreases striatal NT tissue levels, respectively. In contrast, removal of D-2 receptor basal activity with either an antagonist or lesion of the nigrostriatal DA projection increases striatal NT content. To understand better the significance of these changes in the levels of NT peptide, we determined the effects of treatment with the selective D-l agonist, SKF 82958, alone or in combination with a lesion of the nigrostriatal DA pathway, on the levels of NT mRNA in various regions ofthe caudate nucleus. Removal of at least 90% of this DA pathway significantly increased NT mRNA in most, but not all, regions throughout the caudate nucleus. In contrast, four, but not one, administrations of SKF 82958 (2 mgkg(-1) dose(-1)) increased NT mRNA levels in principally middle, but not rostral, caudate regions. Lesioning the nigrostriatal DA pathway enhanced the effects of SKF 82958 so that a lower, single dose (1 mg/kg) of this D-l agonist also increased NT mRNA levels predominantly in the middle caudate sections. These findings demonstrate that DA D-l receptors profoundly regulate the striatal expression of NT mRNA in a regionally selective fashion, which appears to be unique from that principally influenced by DA D-2 regulation. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:15:10