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Titolo:
Large juxtamedullary glomeruli and afferent arterioles in healthy primates
Autore:
Skov, K; Nyengaard, JR; Patwardan, A; Mulvany, MJ;
Indirizzi:
Aarhus Univ, Dept Pharmacol, DK-8000 Aarhus C, Denmark Aarhus Univ Aarhus Denmark C , Dept Pharmacol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp, Dept Nephrol, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Nephrol, DK-8000 Aarhus, Denmark Aarhus Univ Hosp, Stereol Res Lab, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Res Lab, DK-8000 Aarhus, Denmark Royal Inst Technol, Dept Phys 4, S-10044 Stockholm, Sweden Royal Inst Technol Stockholm Sweden S-10044 4, S-10044 Stockholm, Sweden
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 4, volume: 55, anno: 1999,
pagine: 1462 - 1469
SICI:
0085-2538(199904)55:4<1462:LJGAAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ARBITRARY PARTICLES; URINE CONCENTRATION; NUMBER; KIDNEY; SIZE; VOLUME; NEPHROPATHY; MORPHOMETRY; ADAPTATION;
Keywords:
glomerular size; nephron; African green monkey; single nephron glomerular filtration rate; glomerulosclerosis; cortical zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Skov, K Aarhus Univ, Dept Pharmacol, Univ Pk 240, DK-8000 Aarhus C, Denmark Aarhus Univ Univ Pk 240 Aarhus Denmark C K-8000 Aarhus C, Denmark
Citazione:
K. Skov et al., "Large juxtamedullary glomeruli and afferent arterioles in healthy primates", KIDNEY INT, 55(4), 1999, pp. 1462-1469

Abstract

Background Differences in the functional demands of superficial and juxtaglomerular nephrons could result in differences in glomerular size between these two types of nephrons. This concept is based on animal models in whichthe juxtamedullary glomeruli and afferent arteriole diameters are indeed larger than those in the outer cortical zones. However, this difference was not confirmed in human necropsy studies. To obtain further information in living primates, we have made unbiased estimates of glomerular and afferent arteriole dimensions in three cortical zones (superficial, midcortical, andjuxtamedullary) in young, adult, normotensive monkeys. Methods. In each animal (N = 6), the right kidney was perfusion fixed and prepared for unbiased stereological estimation of glomerular number and size. The left kidney vasculature was fixed while relaxed and at a known intravascular pressure. Thereafter, afferent arteriolar dimensions were estimated using light and confocal microscopy. Results. The mean glomerular volume was variable between animals (coefficient of variation, 23%) and was largest in the juxtamedullary zone. Afferentarteriolar lumen diameter varied little between animals (coefficient of variation, 3%), but was also the largest in the juxtamedullary zone. No sclerotic glomeruli were found in any of the animals. Conclusion. The findings show that in normal primates, as previously shownin other animals, juxtamedullary glomeruli and afferent arteriolar diameters are larger compared with those in the outer cortical zones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:56:18