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Titolo:
Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve
Autore:
Mitsui, Y; Schmelzer, JD; Zollman, PJ; Mitsui, M; Tritschler, HJ; Low, PA;
Indirizzi:
Mayo Clin, Dept Neurol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 in, Dept Neurol, Rochester, MN 55905 USA Asta Medica, Frankfurt, Germany Asta Medica Frankfurt GermanyAsta Medica, Frankfurt, Germany
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1, volume: 163, anno: 1999,
pagine: 11 - 16
SICI:
0022-510X(19990201)163:1<11:AAPNFI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL DIABETIC NEUROPATHY; CEREBRAL-ISCHEMIA; BLOOD-FLOW; RAT; PROTECTS; ANTIOXIDANT; CONDUCTION; PRESSURE; EDEMA; HEART;
Keywords:
ischemia-reperfusion injury; peripheral nerve; oxidative stress; alpha-lipoic acid; neuroprotection; sensory conduction velocity; ischemic fiber degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Low, PA Mayo Clin, Dept Neurol, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin 200 1st St SW Rochester MN USA 55905 ester, MN 55905 USA
Citazione:
Y. Mitsui et al., "Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve", J NEUR SCI, 163(1), 1999, pp. 11-16

Abstract

Background: Reperfusion aggravates nerve ischemic fiber degeneration, likely by the generation of reduced oxygen species. We therefore evaluated if racemic alpha-lipoic acid (LA), a potent antioxidant, will protect peripheral nerve from reperfusion injury, using our established model of ischemia-reperfusion injury. Methods: We used male SD rats, 300+/-5 g. Ischemia was produced by the ligature of each of the supplying arteries to the sciatic-tibial nerve of the right hind-limb for predetermined periods of time (either 3 or 5 h), followed by the release of the ligatures, resulting in reperfusion. LA was given intraperitoneally daily for 3 days for both pre- and post-surgery. Animals received either LA, 100 mg/kg/day, or the same volume of saline intraperitoneally. Clinical behavioral score and electrophysiology ofmotor and sensory nerves were obtained at 1 week after ischemia-reperfusion. After electrophysiological examination, the sciatic-tibial nerve was fixed in situ and embedded in epon. We evaluated for ischemic fiber degeneration (IFD) and edema, as we described previously. Results: Distal sensory conduction (amplitude of sensory action potential and sensory conduction velocity (SCV) of digital nerve) was significantly improved in the 3-h ischemia group, treated with LA (P<0.05). LA also improved IFD of the mid tibial nerve (P=0.0522). LA failed to show favorable effects if the duration of ischemia was longer (5-h ischemia). Conclusion: These results suggest that alpha-lipoic acid is efficacious for moderate ischemia-reperfusion, especially on distal sensory nerves. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 30/09/20 alle ore 09:20:39