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Titolo:
Effects of bromocriptine and haloperidol on prepulse inhibition: comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man
Autore:
Abduljawad, KAJ; Langley, RW; Bradshaw, CM; Szabadi, E;
Indirizzi:
Univ Nottingham, Queens Med Ctr, Dept Psychiat, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 13, anno: 1999,
pagine: 3 - 9
SICI:
0269-8811(199903)13:1<3:EOBAHO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; GATING DEFICITS; REFLEX; SENSORIMOTOR; P50; PHARMACOKINETICS; CLOZAPINE; RATS;
Keywords:
acoustic startle response; auditory-evoked potential; bromocriptine; D-2 dopamine receptors; eyeblink; haloperidol; N1/P2 complex; prepulse inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Bradshaw, CM Univottinghamam Hosp, Queens Med Ctr, Dept Psychiat, Floor A,South Block, N Univ Nottingham Hosp Floor A,South Block Nottingham EnglandNG7 2UH
Citazione:
K.A.J. Abduljawad et al., "Effects of bromocriptine and haloperidol on prepulse inhibition: comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man", J PSYCHOPH, 13(1), 1999, pp. 3-9

Abstract

Experiments with animals have shown that D-2 dopamine receptors are involved in regulating prepulse inhibition (PPI) of the acoustic startle reflex (suppression of the reflex response evoked by a loud sound by prior presentation of a low-intensity stimulus). Recently we found that PPI of the human eyeblink startle response could be suppressed by a D-2 receptor agonist, bromocriptine, and that this suppression could be reversed by a D2 receptor-blocking neuroleptic, haloperidol. The present work attempted to replicate this finding and to extend it to PPI of the N1/P2 component of the auditory-evoked potential. Eleven healthy males (18-30 years) participated in four sessions in which they received oral doses of placebo, bromocriptine 1.25 mg, haloperidol 3mg and combined treatment with bromocriptine 1.25mg+haloperidol 3mg, according to a balanced double-blind protocol. Thirty-minute simultaneous recordings of the electromyographic (EMC;) responses of the orbicularis oculi muscle of the right eye and the vertex auditory-evoked potentials took place 120 min after ingestion of haloperidol and/or 90 min after ingestion of bromocriptine. Sound stimuli (1-kHz) were presented in 60 trials separated by variable intervals (mean 25 sec): (i) 40 msec 115 dB ('pulse alone': 20 trials); (ii) 40 msec 85 dB (20 trials); (iii) 40 msec 85 dB, followed after 120 msec by 40 msec 115 dB ('prepulse/pulse': 20 trials). The amplitudes of the EMG and N1/P2 responses were not altered significantly by any of the treatments. Bromocriptine attenuated PPI of the EMC; response significantly, this attenuation being absent following combined haloperidol/bromocriptine treatment. Neither bromocriptine nor haloperidol significantlyaltered PPI of the N1/P2 complex. Bromocriptine suppressed and haloperidolelevated serum prolactin levels, these changes being absent when the two drugs were given in combination. The results suggest that different mechanisms may be involved in regulating PPI of the eyeblink and the N1/P2 component of the auditory-evoked potential, and that D-2 receptors may be involved in the former case, but not the latter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:02:13