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Titolo:
Synergistic interactions between ampakines and antipsychotic drugs
Autore:
Johnson, SA; Luu, NT; Herbst, TA; Knapp, R; Lutz, D; Arai, A; Rogers, GA; Lynch, G;
Indirizzi:
Cortex Pharmaceut Inc, Irvine, CA 92618 USA Cortex Pharmaceut Inc Irvine CA USA 92618 aceut Inc, Irvine, CA 92618 USA
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 1, volume: 289, anno: 1999,
pagine: 392 - 397
SICI:
0022-3565(199904)289:1<392:SIBAAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCINE ADJUVANT THERAPY; GLUTAMATE RECEPTORS; NEGATIVE SYMPTOMS; SCHIZOPHRENIA; FACILITATION; MEMORY; METHAMPHETAMINE; MODULATOR; CURRENTS; KETAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, SA Cortex Pharmaceut Inc, 15231 Barranca Pkwy, Irvine, CA 92618 USA Cortex Pharmaceut Inc 15231 Barranca Pkwy Irvine CA USA 92618
Citazione:
S.A. Johnson et al., "Synergistic interactions between ampakines and antipsychotic drugs", J PHARM EXP, 289(1), 1999, pp. 392-397

Abstract

Tests were made for interactions between antipsychotic drugs ana compoundsthat enhance synaptic currents mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors ("ampakines"). Typical and atypical antipsychotic drugs decreased methamphetamine-induced hyperactivity in rats; the effects of near or even subthreshold doses of the antipsychotics were greatly enhanced by the ampakines. Interactions between the ampakine CX516 and low doses of different antipsychotics were generally additive and often synergistic. The ampakine did not exacerbate neuroleptic-induced catalepsy, indicating that the interaction between the different pharmacological classes was selective. These results suggest that positive modulators of cortical glutamatergic systems may be useful adjuncts in treating schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:24:13